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TranscriptomicsA Systematic Substrate Screen Links Cyclin D-Dependent Kinases to Senescence Suppression in Cancer Cells through FOXM1
Gene expression (mRNA profiling) of U2OS osteosarcoma cells treated with 1 mM of the CDK4/6-specific inhibitor, PD0332991, versus vehicle (DMSO) for 4 hours Here, we monitored the early transcriptional response to acute inhibition of CDK4/6 catalytic activity. As PD0332991 substantially induced sene...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-32182 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human G01518 fibroblasts starved for 16 hours in the presence of 0.1% BSA, and then stimulated for 1, 4, 10 or 24 hours with PDGF-BB (10 ng/ml in starvation medium),
Subconfluent AG01518 fibroblasts were starved for 16 hours in the presence of 0.1% BSA, and then stimulated for 1, 4, 10 or 24 hours with PDGF-BB (10 ng/ml in starvation medium), or left untreated for the same periods of time. Total RNA was isolated using the RNeasy kit (Qiagen). The RNA quality was...
ORGANISM(S): Homo sapiens 
2004-06-30 | E-MEXP-126 | biostudies-arrayexpress
GenomicsThe Danish Reference Genome - GenomeDenmark data access committee
Data Access Committee EGAC00001000562
EGAC00001000562 | EGA
TranscriptomicsBATSeq of ESC-FCS/ESC-2i/NSC
Single-cell polyadenylation site quantification 48 single cells each of murine embryonic stem cells maintained in FCS+LIF medium ("ESC"), embryonic stem cells maintained in serum free, 2i containing medium ("2i") and neural stem cells ("NSC") were sequenced by BATSeq, a...
ORGANISM(S): Mus musculus 
2015-06-09 | E-GEOD-60768 | biostudies-arrayexpress
MetabolomicsLarge-scale non-targeted plasma metabolomics in the Uppsala Longitudinal Study of Adult Men
The Uppsala Longitudinal Study of Adult Men (ULSAM) study is an ongoing, longitudinal, epidemiologic study started in 1970 and based on men born between 1920 and 1924 in Uppsala, Sweden which were invited to participate at age 50 (N=2,841) [PMID: 9484991]; 81.7% (N=2,322) participated. Individuals w...
2015-03-23 | MTBLS124 | MetaboLights
MetabolomicsLarge-scale non-targeted serum metabolomics in the Prospective Investigation of the Vasculature in Uppsala Seniors
The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) is a community-based study where all men and women at age 70 living in Uppsala, Sweden were invited to participate in 2001. The 1,016 participants (50% women) have been extensively phenotyped. In March 2006 a reinvesigation ...
2014-08-30 | MTBLS90 | MetaboLights
GenomicsChIP-Seq for cofactors in cancer
Critical drivers of cancer progression are likely controlled through the actions of transcription factors and cofactors that bind to the genome and form enhancers that stimulate gene expression. We present ChIP-seq analysis of key transcriptional regulators, cofactors and histone modifications that...
ORGANISM(S): Homo sapiens 
2013-04-13 | E-GEOD-45984 | biostudies-arrayexpress
GenomicsChem-Seq of chemical derivatives in MM1S cells
An ability to map the global interactions of a chemical entity with chromatin genome-wide could provide new insights into the mechanisms by which a small molecule perturbs cellular functions. we developed a method that uses chemical derivatives and massively parallel DNA sequencing (Chem-Seq) to ide...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-44098 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Enterococcus faecalis isolates from European hospital environments
Comparative genomic hybridization of 15 strains isolated in European hospital environments and selected for CGH based on MLST sequence types
ORGANISM(S): Enterococcus faecalis 
2010-08-01 | E-TABM-905 | biostudies-arrayexpress
no omics definedTranscription profiling of Enterococcus faecalis V583 in response to NaCl
The effects of NaCl on transcriptional events were studied by means of genome wide microarrays in Enterococcus faecalis V583. Transcriptional profiles were obtained through time series experiments over periods of 60min.
ORGANISM(S): Enterococcus faecalis 
2010-08-01 | E-TABM-904 | biostudies-arrayexpress
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