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ProteomicsCross-species analysis of viral nucleic acid interactors identifies TAOKs as immune regulators
The cell intrinsic antiviral response of multicellular organisms developed over millions of years and critically relies on the ability to sense and eliminate viral nucleic acids. Here we used an affinity proteomics approach in evolutionary distant species (human, mouse and fly) to identify proteins ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Drosophila melanogaster (Fruit fly) 
2021-09-22 | PXD027894 | Pride
Ap-ms Lc-ms/ms 
TranscriptomicsMolecular anatomy of gene expression responses in stressed hepatocytes
It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in live...
ORGANISM(S): Mus musculus 
2016-09-28 | E-MTAB-4444 | biostudies-arrayexpress
ProteomicsCross-species analysis of viral nucleic acid interactors identifies TAOKs as immune regulators
The cell intrinsic antiviral response of multicellular organisms developed over millions of years and critically relies on the ability to sense and eliminate viral nucleic acids. Here we used an affinity proteomics approach in evolutionary distant species (human, mouse and fly) to identify proteins ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD027896 | Pride
Ap-ms Lc-ms/ms 
ProteomicsCross-species analysis of viral nucleic acid interactors identifies TAOKs as immune regulators
The cell intrinsic antiviral response of multicellular organisms developed over millions of years and critically relies on the ability to sense and eliminate viral nucleic acids. Here we used an affinity proteomics approach in evolutionary distant species (human, mouse and fly) to identify proteins ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD027919 | Pride
Ap-ms Lc-ms/ms 
ProteomicsNUDT2 Knockout full proteome mouse
Proteome comparison between bone-marrow cells isolated from wildtype and NUDT2 knockout mice.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD023219 | Pride
Mouse Full proteome Lc-ms Nudix hydolases Bone-marrow 
ProteomicsRecombinant dimeric PICK1 protein inhibitors for long-term relief of chronic pain by AAV therapeutics
Chronic neuropathic pain’s impact, persistence, and limited treatments render it relevant for gene therapy. Here, we describe the development and application of self-assembling dimeric peptide inhibitors of the pain-associated scaffolding protein PICK1 (protein interacting with C-kinase 1) delivered...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD074049 | Pride
Pick1  protein interacting with c-kinase 1  neuropathic pain Pain treatment  neuropathic pain treatment  gene therapy  aav therapeutics. 
ProteomicsRecombinant dimeric PICK1 protein inhibitors for long-term relief of chronic pain by AAV therapeutics
Chronic neuropathic pain’s impact, persistence, and limited treatments render it relevant for gene therapy. Here, we describe the development and application of self-assembling dimeric peptide inhibitors of the pain-associated scaffolding protein PICK1 (protein interacting with C-kinase 1) delivered...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD073925 | Pride
Pick1  protein interacting with c-kinase 1  neuropathic pain Pain treatment  neuropathic pain treatment  gene therapy  aav therapeutics 
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