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ProteomicsCoordination of fungal biofilm development by extracellular vesicle cargo
The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the immune system. The biofilm cells release extracellular vesicles (EVs) that promote extracellular matrix formation and resistance to antifungal drugs. Here, we define functions for numerous EV cargo proteins in ...
ORGANISM(S): Candida albicans (Yeast) 
2022-02-16 | PXD028596 | Pride
Candida albicans Extracellular vesicles Matrix proteomics Biofilm Biofilms 
Other,MultiomicsChevrette et al 2019 Insect-associated Streptomyces
Paper title: The antimicrobial potential of Streptomyces from insect microbiomes. Author list: Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo ...
ORGANISM(S): Pseudonocardia Kitasatospora Streptomyces Gordonia <actinomycete> 
2019-12-18 | MSV000084723 | MassIVE
ProteomicsCandida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses
Extracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication. Fungal EVs contain numerous factors involved in a diverse array ...
ORGANISM(S): Candida albicans SC5314 
2025-05-26 | PXD045873 | Pride
Candida albicans Biofilm Vesicles 
ProteomicsCandida auris proteomic profiling
In this study, we designed a novel antifungal agent, PQA-Az-13 that demonstrated antifungal activity against C. auris biofilms. Cellular proteomics indicated that PQA-Az-13 partially or completely inhibited numerous enzymatic proteins in C. auris biofilms, particularly those involved in both amino a...
ORGANISM(S): [Candida] auris 
2023-12-07 | PXD046911 | Pride
Candida auris Biofilm Ex vivo skin colonization 
Metabolomics,MultiomicsGNPS - Chevrette et al 2019 Insect-associated Streptomyces
Paper title: The antimicrobial potential of Streptomyces from insect microbiomes. Author list: Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo ...
ORGANISM(S): Kitasatospora (ncbitaxon:2063) Gordonia <actinomycete> (ncbitaxon:2053) Pseudonocardia (ncbitaxon:1847) Streptomyces (ncbitaxon:1883) 
2019-12-18 | MSV000084723 | GNPS
ProteomicsVesicle proteomics during fungal biofilm development in Candida
Proteomic profiling of extracellular vesicles from four different Candida strains (tropicalis, parapsilosis, auris and glabrata).
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) [Candida] auris Candida parapsilosis Candida tropicalis (Yeast) 
2022-10-14 | PXD035068 | Pride
Extracellular vesicles Candida Biofilm Lc-ms/ms 
TranscriptomicsRegulatory role of glycerol in Candida albicans biofilm formation
Biofilm formation on medically implanted devices by Candida albicans poses a significant clinical challenge. Here we compared biofilm-associated gene expression in two clinical C. albicans isolates, SC5314 and WO-1, to identify shared gene regulatory responses that may be functionally relevant. Amon...
ORGANISM(S): Candida albicans 
2013-04-12 | E-GEOD-45141 | biostudies-arrayexpress
ProteomicsAntifungal turbinmicin alters functional vesicle cargo
Extracellular vesicle delivery in Candida biofilms is important for matrix delivery and associated drug-resistance. Prior study found the antifungal turbinmicin inhibits vesicle release. We find the antifungal turbinmicin inhibits both vesicle release as well as cargo loading. Using comparative vesi...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-06 | PXD076431 | Pride
Turbinmicin Proteomics Candida Extracellular vesicles 
ProteomicsGlobal identification of biofilm-specific proteolysis in Candida albicans
The global extracellular protease substrate specificity of C. albicans under biofilm and planktonic (suspension) conditions was determined with a synthetic library of 14-mer peptide substrates using an approach termed Multiplex Substrate Profiling by Mass Spectrometry (MSP-MS). Shotgun proteomics an...
ORGANISM(S): Candida Albicans (ncbitaxon:5476) 
2016-03-09 | MSV000079564 | MassIVE
TranscriptomicsIdentification and characterization of potent, broad-spectrum antifungal compounds using a yeast reporter bioassay.
New antifungal drugs are urgently needed due to the currently limited selection, the emergence of drug resistance, and the toxicity of several commonly used drugs. To identify drug leads, we screened small molecules using a Saccharomyces reporter bioassay in which the yeast heterologously expresses...
ORGANISM(S): Candida albicans 
2012-04-30 | E-GEOD-35105 | biostudies-arrayexpress
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