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ProteomicsUrinary proteomics by 2DE and LC-MS/MS
Despite research progresses, the chance to accurately predict the risk for diabetic nephropathy (DN) is still poor. Our goal is to develop new predictive tools of nephropathy starting from urine, which can be easily obtained using noninvasive procedures and it is directly related to kidney. In this ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-04 | PXD011183 | Pride
Type 1 diabetes Urine Predictive biomarkers Diabetic nephropathy 
ProteomicsProteomic profile of extracellular matrix-based scaffold obtained by culturing a murine spleen stromal cell line
Lymph nodes are secondary lymphoid tissues that play a critical role in filtering the lymph and supporting adaptive immune responses. Surgical resection of LNs, radiation therapy or infections may damage lymphatic vasculature and compromised immune functions. Here, we describe the generation of func...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD013250 | Pride
Lympho-organoids Transplantation Extracellular matrix Mouse 
ProteomicsDUX4 interactors by LC-MSMS
The aim of this study is to define the molecular mechanisms underlying DUX4-associated toxicity in the context of facioscapulohumeral muscular dystrophy (FSHD). DUX4 is a transcription factor, which induces cell death by activating the transcription of its targets. No molecule able to directly contr...
ORGANISM(S): Homo sapiens (Human) 
2023-08-21 | PXD011073 | Pride
Human cells Matr3 Dux4 Fshd muscular dystrophy 
ProteomicsProteomic analysis of extracellular vesicles and conditioned medium from human Adipose-derived Stem/Stromal Cells and Dermal Fibroblasts
Conditioned medium (CM) and extracellular vesicles (EV) from human Adipose-derived Stem/stromal cells (ASC) and Dermal fibroblasts (DF) can represent valid cell substitutes in regenerative medicine and other therapeutic applications. Whether one of the two cell products should be preferred over the ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020219 | Pride
Adipose-derived stromal cells Label-free quantitative proteomics Extracellular vesicles Dermal fibroblasts Conditioned medium Secretome 
ProteomicsInteractome of the long non-protein coding RNA (lncRNA) D4Z4 binding element-transcript (DBE-T)
Facioscapulohumeral muscular dystrophy (FSHD) is an inherited progressive neuromuscular disorder that afflicts both children and adults regardless of gender. FSHD is caused by aberrant gain of expression of the transcription factor DUX4, which triggers a pro-apoptotic transcriptional program leading...
ORGANISM(S): Homo sapiens (Human) 
2023-04-11 | PXD036038 | Pride
Facioscapulohumeral muscular dystrophy (fshd) Long non-protein coding rna Affinity proteomics 
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
ProteomicsProtein composition of the extracellular matrix in idiopathic germ cell aplasia
The somatic microenvironment supports spermatogonial stem cell differentiation into sperm. Extracellular matrix (ECM) plays multiple roles in the stem cell niche, including self-renewal, proliferation, differentiation and survival of spermatogonial cells. The pathophysiology of male infertility mig...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011817 | Pride
Extracellular matrix  male infertility  label-free quantitative proteomics 
ProteomicsProteomics analysis of the SIRT1 activating compound SRT2104 effect on tibialis anterior muscle in Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a rare and devastating genetic disorder, whose management is still a major challenge, despite progress in genetic and pharmacological disease-modifying treatments have been made. Mitochondrial dysfunctions contribute to DMD, however, there are no effective mitoch...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD054747 | Pride
Acetylome Mdx mice Proteomics Sirtuin 1 Duchenne muscular dystrophy 
ProteomicsProteomics analysis of cerebrospinal fluid (CSF) from multiple sclerosis patients
Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represents an unmet need. Neural precursor cells (NPCs) transplanted in animal models of multiple sclerosis promote neuroprotection and remyelination by releasin...
ORGANISM(S): Homo sapiens (Human) 
2022-11-18 | PXD034846 | Pride
Progressive multiple sclerosis Cerebrospinal fluid Neural stem cells Transplantation Quantitative proteomics 
ProteomicsProteomics analysis of cerebrospinal fluid (CSF) from multiple sclerosis patients
Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represents an unmet need. Neural precursor cells (NPCs) transplanted in animal models of multiple sclerosis promote neuroprotection and remyelination by releasin...
ORGANISM(S): Homo sapiens (Human) 
2022-11-18 | PXD034840 | Pride
Progressive multiple sclerosis Cerebrospinal fluid Neural stem cells Transplantation Quantitative proteomics 
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