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TranscriptomicsTranscription profiling of human prostate samples LNCaP cell gene expression during 12 months of androgen deprivation, time series
Following androgen ablation therapy (AAT), the vast majority of prostate cancer patients develop treatment resistance with a median time of 18-24 months to disease progression. To identify molecular targets that aid in prostate cancer cell survival and contribute to the androgen independent phenotyp...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-8702 | biostudies-arrayexpress
ProteomicsAndrogen receptor RIME using LNCaP cells
Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) was conducted to examine interactome of androgen receptor (AR) in LNCaP cells.
ORGANISM(S): Homo Sapiens (human) 
2021-09-10 | PXD024030 | JPOST Repository
TranscriptomicsThe effect of androgen deprivation on human prostate xenograft tumor LuCaP35
Androgen deprivation is a standard of care front-line therapy for human prostate cancer, however, majority of patients will eventally develop resistance to androgen deprivation. In this study, using a human prostate cancer xenograft model -LuCaP35, we examiend the gene expression changes after castr...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-33316 | biostudies-arrayexpress
TranscriptomicsHypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.
Hypoxia inducible factor 1 (HIF1) has been shown to cooperate with the androgen receptor (AR) in activation of oncogenic pathways in prostate cancer (PCa). Here we hypothesized that HIF1 also plays a role in PCa response to androgen deprivation therapy (ADT). Comparison of gene expression profiles o...
ORGANISM(S): Homo sapiens 
2013-10-02 | E-GEOD-42868 | biostudies-arrayexpress
ProteomicsThe effects of enzalutamide on androgen-dependent and androgen-independent prostate cancer cells.
To investigate the mechanisms of drug resistance and castration resistance in prostate cancer, we performed proteomic sequencing on androgen-dependent prostate cancer cells (LNCaP) and androgen-independent cells (AI) treated with enzalutamide.
ORGANISM(S): Homo Sapiens 
2024-11-26 | PXD058261 |
GenomicsPersistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions
The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR ...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-40050 | biostudies-arrayexpress
GenomicsAndrogen deprivation therapy promotes an inflammatory and obesity-like microenvironment in periprostatic fat
Prostate cancer is a leading cause of cancer-related death and morbidity worldwide. Androgen deprivation therapy (ADT) is the cornerstone of management for advanced disease. The use of androgen deprivation therapies is associated with multiple side effects, including metabolic syndrome and truncal o...
EGAS00001003286 | EGA
ProteomicsProteomics Analysis of Skeletal Muscle in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy
Prostate cancer (PCa) is the second most common cancer in men and negatively impact muscle mass, physical function, and patient-reported outcomes. Androgen deprivation therapy (ADT) is a widely used treatment for advanced disease, but it exacerbates these adverse effects. To investigate the molecula...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD061070 | Pride
Skeletal muscle Androgen deprivation therapy Data-independent acquisition Prostate cancer 
TranscriptomicsIdentification of an SRF- and androgen-dependent gene signature in prostate cancer
The androgen receptor (AR) is the principal target for treatment of non-organ confined prostate cancer (PCa). Systems and bioinformatics approaches suggest that considerable variation exists in the mechanisms by which AR regulates expression of effector genes and point towards a role for secondary ...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-22606 | biostudies-arrayexpress
TranscriptomicsRat ventral prostate gland gene profile after androgen deprivation
Androgens are required for prostate development, growth and physiology, by activating the androgen receptor (AR) upon activation by testosterone and dihydrotestosterone (DHT), the AR undergoes conformational changes, dimerizes and translocates to the cell nucleus regulation important genes releted t...
ORGANISM(S): Rattus norvegicus 
2015-03-28 | E-GEOD-56289 | biostudies-arrayexpress
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