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TranscriptomicsTranscription profiling of human prostate samples LNCaP cell gene expression during 12 months of androgen deprivation, time series
Following androgen ablation therapy (AAT), the vast majority of prostate cancer patients develop treatment resistance with a median time of 18-24 months to disease progression. To identify molecular targets that aid in prostate cancer cell survival and contribute to the androgen independent phenotyp...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-8702 | biostudies-arrayexpress
TranscriptomicsHypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.
Hypoxia inducible factor 1 (HIF1) has been shown to cooperate with the androgen receptor (AR) in activation of oncogenic pathways in prostate cancer (PCa). Here we hypothesized that HIF1 also plays a role in PCa response to androgen deprivation therapy (ADT). Comparison of gene expression profiles o...
ORGANISM(S): Homo sapiens 
2013-10-02 | E-GEOD-42868 | biostudies-arrayexpress
TranscriptomicsThe effect of androgen deprivation on human prostate xenograft tumor LuCaP35
Androgen deprivation is a standard of care front-line therapy for human prostate cancer, however, majority of patients will eventally develop resistance to androgen deprivation. In this study, using a human prostate cancer xenograft model -LuCaP35, we examiend the gene expression changes after castr...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-33316 | biostudies-arrayexpress
GenomicsAndrogen deprivation therapy promotes an inflammatory and obesity-like microenvironment in periprostatic fat
Prostate cancer is a leading cause of cancer-related death and morbidity worldwide. Androgen deprivation therapy (ADT) is the cornerstone of management for advanced disease. The use of androgen deprivation therapies is associated with multiple side effects, including metabolic syndrome and truncal o...
EGAS00001003286 | EGA
ProteomicsAndrogen receptor RIME using LNCaP cells
Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) was conducted to examine interactome of androgen receptor (AR) in LNCaP cells.
ORGANISM(S): Homo Sapiens (human) 
2021-09-10 | PXD024030 | JPOST Repository
ProteomicsProteomics Analysis of Skeletal Muscle in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy
Prostate cancer (PCa) is the second most common cancer in men and negatively impact muscle mass, physical function, and patient-reported outcomes. Androgen deprivation therapy (ADT) is a widely used treatment for advanced disease, but it exacerbates these adverse effects. To investigate the molecula...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD061070 | Pride
Skeletal muscle Androgen deprivation therapy Data-independent acquisition Prostate cancer 
ProteomicsThe effects of enzalutamide on androgen-dependent and androgen-independent prostate cancer cells.
To investigate the mechanisms of drug resistance and castration resistance in prostate cancer, we performed proteomic sequencing on androgen-dependent prostate cancer cells (LNCaP) and androgen-independent cells (AI) treated with enzalutamide.
ORGANISM(S): Homo Sapiens 
2024-11-26 | PXD058261 |
TranscriptomicsThe Wnt/β-catenin-signaling pathway is modulated by androgen ablation therapy for advanced clinical prostate cancer and contributes to androgen independent cell growth
Androgen ablation therapy (AAT) is standard treatment for locally-advanced/metastatic prostate cancer (PCa). Many patients develop castration-resistance (CRPCa) after ~2-3 years, with a poor prognosis. The molecular mechanisms underlying CRPCa progression are unclear. mRNA-Seq was performed on tu...
ORGANISM(S): Homo sapiens 
2013-10-07 | E-GEOD-48403 | biostudies-arrayexpress
ClinicalA continence promotion intervention involving a pelvic floor muscle rehabilitation exercise program to reduce lower urinary tract, lower bowel symptoms and erectile dysfunction in men receiving radiation therapy with or without androgen deprivation therapy (ADT): A Pilot Study
Interventions: A specifically designed continence promotion intervention including a tailored pelvic floor muscle rehabilitation exercise program to reduce lower urinary tract , lower bowel symptoms and erectile dysfunction in men receiving radiation therapy with 6 months no-adjuvant androgen depriv...
2458234 | ecrin-mdr-crc
TranscriptomicsRat ventral prostate gland gene profile after androgen deprivation
Androgens are required for prostate development, growth and physiology, by activating the androgen receptor (AR) upon activation by testosterone and dihydrotestosterone (DHT), the AR undergoes conformational changes, dimerizes and translocates to the cell nucleus regulation important genes releted t...
ORGANISM(S): Rattus norvegicus 
2015-03-28 | E-GEOD-56289 | biostudies-arrayexpress
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