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ProteomicsThe effects of enzalutamide on androgen-dependent and androgen-independent prostate cancer cells.
To investigate the mechanisms of drug resistance and castration resistance in prostate cancer, we performed proteomic sequencing on androgen-dependent prostate cancer cells (LNCaP) and androgen-independent cells (AI) treated with enzalutamide.
ORGANISM(S): Homo Sapiens 
2024-11-26 | PXD058261 |
TranscriptomicsAndrogen receptor-independent function of FoxA1 in prostate cancer metastasis
FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-37314 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells.
Epidemiological studies provide strong evidence that consumption of cruciferous vegetables, such as broccoli, can significantly reduce the risk of developing cancers. Sulforaphane (SFN), a phytochemical derived from cruciferous vegetables, induces anti-proliferative and pro-apoptotic responses in pr...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-48812 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human androgen-dependent and androgen-independent primary prostate cancer tumors
Affymetrix U133A comparison of two groups (10 samples each): untreated (androgen-dependent) primary prostate cancer (Gleasons 5-9) and androgen-independent primary prostate cancer. All samples were microdissected for tumor cells only.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2443 | biostudies-arrayexpress
TranscriptomicsTranscriptional programs activated by exposure of human prostate cancer cells to androgen.
Androgens are required for both normal prostate development and prostate carcinogenesis. We used DNA microarrays, representing approximately 18,000 genes, to examine the temporal program of gene expression following treatment of the human prostate cancer cell line LNCaP with a synthetic androgen. ...
ORGANISM(S): Homo sapiens 
2005-10-15 | E-GEOD-3451 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate samples LNCaP cell gene expression during 12 months of androgen deprivation, time series
Following androgen ablation therapy (AAT), the vast majority of prostate cancer patients develop treatment resistance with a median time of 18-24 months to disease progression. To identify molecular targets that aid in prostate cancer cell survival and contribute to the androgen independent phenotyp...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-8702 | biostudies-arrayexpress
TranscriptomicsAn Integrated Network of Androgen Receptor and TMPRSS2-ERG Gene Fusion in Prostate Cancer Progression (II)
Androgen receptor (AR) is a transcription factor that plays a central role in the growth and development of the normal prostate and its malignant transformation. More recently, a majority of prostate cancers have been shown to harbor recurrent gene fusions of the androgen-regulated gene, TMPRSS2, t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-14092 | biostudies-arrayexpress
TranscriptomicsExpression data from prostate cancer cell lines LNCap (androgen dependent) and DU145 (androgen independent), transfected with Pin1 or control siRNA
Pin1 inhibiton exerts anti-oncogenic effects on LNCaP and DU145 cells despite the gene regulation patterns by Pin1 were different in both cells. We investigated how Pin1 modulates the gene expressions in the androgen-dependent as well as the androgen-independent prostate cancer cell lines For the kn...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-67457 | biostudies-arrayexpress
TranscriptomicsGene expression programs of histologically distinct stages of prostate carcinogenesis in Nkx3.1; Pten mutant mice
Key histological and growth progression characteristics of human prostate cancer are phenocopied in mouse models that have been subjected to androgen level depletion and engineered for hemizygosity of candidate prostate cancer tumor suppressor genes Nkx3.1 and Pten. To characterize their relative tr...
ORGANISM(S): Mus musculus 
2009-10-31 | E-GEOD-15943 | biostudies-arrayexpress
GenomicsGenome wide analysis of AR binding sites and histone modifications in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and histone modifications.In addition, by siRNA mediated knockdown of AR-associated factors, changes of AR-binding sit...
ORGANISM(S): Homo sapiens 
2015-02-08 | E-GEOD-62492 | biostudies-arrayexpress
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