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TranscriptomicsExpression data from Drosophila S2 cells depleted of exosome subunits
The exosome complex and its' subunits are vital for proccessing and or degrading many cellular RNAs. We used microarrays to detail the global changes in mRNA levels in response to exosome subunit depletion. RNA was extracted from dsRNA treated S2 cells and hybridized using Affymetrix microarrays. We...
ORGANISM(S): Drosophila melanogaster 
2010-04-12 | E-GEOD-17874 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cartilage tumours IGFBP-3 reveals is regulated by Gli signaling in cartilage tumors.
Mice that develop benign cartilage lesions due to overexpression of Gli2 in chondrocytes developed lesions similar to chondrosarcomas when also deficient in p53. Gli2 overexpression and p53 deficiency had opposing effects on chondrocyte differentiation, but had additive effects negatively regulatin...
ORGANISM(S): Mus musculus 
2009-03-14 | E-GEOD-15118 | biostudies-arrayexpress
UnknownAge- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
Not available
S-EPMC5019754 | biostudies-literature
TranscriptomicsGenome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila
Chromatin insulators are functionally conserved DNA-protein complexes that are situated throughout the genome and organize independent transcriptional domains.  Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the mechanisms by which RNA affects insulat...
ORGANISM(S): Drosophila melanogaster 
2013-01-29 | E-GEOD-41950 | biostudies-arrayexpress
UnknownThe glycome of normal and malignant plasma cells.
Not available
S-EPMC3873332 | biostudies-literature
UnknownCharacterization of the Drosophila melanogaster Dis3 ribonuclease.
Not available
S-EPMC2787996 | biostudies-literature
TranscriptomicsPronounced and Extensive Microtubule Defects in a Saccharomyces cerevisiae DIS3 Mutant
The recently proposed exozyme hypothesis posits that subunits of the RNA processing exosome assemble into structurally distinct protein complexes that function in disparate cellular compartments and RNA metabolic pathways. Here, in a genetic test of this hypothesis, we examine the role of Dis3 -- a...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-01 | E-GEOD-29018 | biostudies-arrayexpress
UnknownThe ribonuclease Dis3 is an essential regulator of the developmental transcriptome.
Not available
S-EPMC3434026 | biostudies-literature
UnknownBreast cancer family history and allele-specific DNA methylation in the legacy girls study.
Not available
S-EPMC5997170 | biostudies-literature
UnknownIdentification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions.
Not available
S-EPMC3995140 | biostudies-literature
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