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MetabolomicsHyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment

Introduction

Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated w...
2022-02-07 | MTBLS2150 | MetaboLights
UnknownMorphological Description and Molecular Characterisation of Glyptothoa gen. nov., a Fish Parasitic Deep-sea Cymothoid (Crustacea: Isopoda) from the Indian Ocean, with Four Species, Including One New Species.
Not available
S-EPMC10689200 | biostudies-literature
MetabolomicsMetabolomics Characterization of Human Calcific Aortic Valve Stenosis

BACKGROUND: Calcific aortic valve stenosis (CAVS) is the most prevalent valvular heart disease in developed countries with significant morbidity and mortality. Given the poor understanding of the pathophysiological processes leading to CAVS, we utilized a joint non-targeted metab...

2020-02-03 | MTBLS1267 | MetaboLights
MetabolomicsPostprandial Metabolism is Impaired in Overweight Normoglycemic Young Adults without Family History of Diabetes

While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of transition from normal to a prediabetes state are unidentified. We studied the basal metabolism and metabolic response to a mixed-meal challenge in 110 healthy subjects in the age group of 18 to 40 years (Mal...

2019-03-14 | MTBLS743 | MetaboLights
ProteomicsLabel-free quantitative Proteomics Analysis Reveals Distinct Molecular characteristics in Endocardial Endothelium
Endocardial endothelium, which lines the chambers of the heart, is distinct in its origin, structure, and function. However, though functionally very important, no studies at protein level have been conducted so far characterizing endocardial endothelium. In this study, we used endothelial cells fro...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-06-29 | PXD009194 | Pride
Aorta Label free proteomics Endocardium Endothelium 
MetabolomicsUntargeted metabolomics reveals alterations in metabolites of lipid metabolism and immune pathways in serum of rats after long term oral administration of Amalaki rasayana
Amalaki rasayana (AR), a traditional preparation is widely used by Ayurvedic physicians for the treatment of inflammatory conditions, cardiovascular diseases, cancer and for rejuvenating aged people. Metabolic alterations induced by Amalaki rasayana intervention are unknown. We aimed to investigate ...
2019-05-24 | MTBLS867 | MetaboLights
ProteomicsProtein profiling of Aortic-Valvular and Endocardial endothelial cells using label-free proteomics
The variations in the protein profile of aortic-valvular (AVE) and endocardial endothelial (EE) cells are currently unknown. The current study's objective is to identify differentially expressed proteins and associated pathways in both endothelial cells. We used endothelial cells isolated from the p...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD025922 | Pride
Endocardial endothelial (ee) cells Aortic-valvular (ave) Lc-ms/ms 
MetabolomicsEFO: In preparation - Early Metabolic Predictors of Type 2 Diabetes Mellitus in Normoglycemic Adults: Insights from Six-Year Prospective Cohort Study

INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often preceded by latent metabolic disruptions. Early detection of metabolic alterations can facilitate timely intervention to delay or prevent T2DM onset. Metaboli...

2025-08-04 | MTBLS10965 | MetaboLights
UnknownProteomics Analysis Reveals Diverse Molecular Characteristics between Endocardial and Aortic-Valvular Endothelium.
Not available
S-EPMC8304717 | biostudies-literature
UnknownExploiting butyrylcholinesterase inhibitors through a combined 3-D pharmacophore modeling, QSAR, molecular docking, and molecular dynamics investigation.
Not available
S-EPMC10035067 | biostudies-literature
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