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TranscriptomicsTranscription profiling of maize segmental aneuploid to study phenotypic and gene expression changes associated with aneuploidy
ABSTRACT: BACKGROUND: While changes in chromosome number that result in aneuploidy are associated with phenotypic consequences such as Down syndrome and cancer, the molecular causes of specific phenotypes and genome-wide expression changes that occur in aneuploids are still being elucidated. RESULTS...
ORGANISM(S): Zea mays 
2008-06-11 | E-GEOD-10243 | biostudies-arrayexpress
TranscriptomicsUniform response to aneuploidy in human cells
There are many different types and origins of aneuploidy, but whether there is a uniform cellular response to aneuploidy in human cells has not been addressed so far. To uncover a uniform transcriptional response to aneuploidy we evaluted the transcription profiles of trisomic and tetrasomic cell li...
ORGANISM(S): Homo sapiens 
2014-02-19 | E-GEOD-47830 | biostudies-arrayexpress
TranscriptomicsThe effect of aneuploidy on gene expression
Analysis of the gene expression changes observed in aneuploid b1 integrin YYFF MEFs generated as a result of repeated cytokinesis failure compared to tetraploid wild-type MEFs or tetraploid b1YYFF integrin MEFs. The results reveal aneuploidy-specific gene expression changes, both up-and downregulate...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-23729 | biostudies-arrayexpress
TranscriptomicsAneuploidy-induced cellular stresses limit autophagic degradation.
An unbalanced karyotype, a condition known as aneuploidy, has a profound impact on cellular physiology and is a hallmark of cancer. Determining how aneuploidy affects cells is thus critical to understanding tumorigenesis. Here we show that aneuploidy interferes with the degradation of autophagosomes...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-60570 | biostudies-arrayexpress
GenomicsSingle-cell whole-genome sequencing of aneuploid cycling and aneuploid arrested cells
Single-cell whole-genome sequencing of aneuploid cycling and aneuploid arrested cells
PRJEB58407 | ENA
TranscriptomicsChromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue.
The mucosae of the oral cavity are different at the histological level but are all exposed to common genotoxic agents. As a result of this exposure, changes in the mucosal epithelia develop giving rise to Oral Potentially Malignant Lesions (OPMLs), which with time may in turn progress to Oral Squamo...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-28868 | biostudies-arrayexpress
TranscriptomicsSNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts
Preimplantation genetic diagnosis (PGD) of aneuploidy by fluorescence in situ hybridisation (FISH) has not delivered the expected clinical benefit. Many previous re-analysis studies of embryos deemed aneuploid by FISH on day 3 have found a high degree of chromosomal normalcy at the blastocyst stage...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-18932 | biostudies-arrayexpress
GenomicsA collection of Candida albicans aneuploid strains
A collection of Candida albicans aneuploid strains
PRJEB41161 | ENA
ProteomicsProteomics analysis of 2n+x aneuploid yeast
We generated forty 2n+x aneuploid yeast strains and qualify the proteomes in nine of them using SILAC.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-05-23 | PXD007157 | Pride
2n+x Aneuploid Silac 
TranscriptomicsTranscription profiling by array of human oocytes to investigate the association between meiotic aneuploidy and altered oocyte gene expression
This study combined a comprehensive cytogenetic investigation of oocytes with a detailed assessment of their transcriptome. The 1st polar body was removed from all oocytes and aneuploidy assessed using comparative genomic hybridization. mRNA transcript data was produced with the use of microarrays ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-MEXP-2745 | biostudies-arrayexpress
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