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ProteomicsAtherosclerotic environment effect over CAC pre-angiogenic role
In response to vascular injury, early EPC or Circulating angiogenic cells (CAC) are thought to be recruited to the damaged areas, participating mainly in a paracrine fashion, by releasing pro-angiogenic factors, promoting the mobilization of other cell populations such as the late EPC, or endothelia...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019395 | Pride
Proteomics Angiogenesis Circulating angiogenic cells Atherosclerotic factors Paracrine role Endothelial colony forming cells Secretome 
ProteomicsLong-term changes following pre-conditioned circulating angiogenic cells therapy in critical limb ischemia
Critical limb ischemia (CLI), results from a severe blockade of the arterial vessels, is usually correlated to atherosclerosis. Circulating angiogenic cells (CACs) constitute a good alternative as CLI cell therapy due to their vascular regenerative potential, although the mechanisms of action of the...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD024132 | Pride
Neovascularization Circulating angiogenic cells Immune cells Atherosclerotic secretome Critical limb ischemia 
TranscriptomicsRNAi knock down of human breast cancer cell line MCF10A with BCRA1 or CtIP-RNAi reveals removal of the BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature
BRCA1 exerts transcriptional repression through interaction with CtIP in the C-terminal BRCT domain and ZBRK1 in the central domain. A dozen genes, including angiopoietin-1 (ANG1), a secreted angiogenic factor, are corepressed by BRCA1 and CtIP based on microarray analysis of mammary epithelial cell...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4754 | biostudies-arrayexpress
GenomicsCirculating angiogenic profiles in ischemic stroke and intracranial atherosclerosis (ICAD)
Circulating angiogenic profiles in ischemic stroke and intracranial atherosclerosis (ICAD)
PRJNA1380502 | ENA
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Treatment]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78960 | biostudies-arrayexpress
UnknownArterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors.
Not available
S-EPMC4423857 | biostudies-literature
UnknownBACH1-mediated transcriptional repression of pro-angiogenic factors drives angiogenic impairment in hypertension.
Not available
S-EPMC12932592 | biostudies-literature
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Cell Model]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78959 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of human MCF10A cells in 3-D culture for 15 h after treatment with BRCA1-RNAi vs Luc-RNAi adenovirus
BRCA1 exerts transcriptional repression through interaction with CtIP in the C-terminal BRCT domain and ZBRK1 in the central domain. A dozen of genes including angiopoietin-1 (ANG1), a secreted angiogenic factor, are co-repressed by BRCA1 and CtIP based on microarray analysis of mammary epithelial c...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4750 | biostudies-arrayexpress
GenomicsEpigenetic enhancer modifications determine the angiogenic to quiescent endothelial state transition
Epigenetic enhancer modifications determine the angiogenic to quiescent endothelial state transition
PRJNA1236325 | ENA
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