Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human HMVEC cells treated with vascular endothelial growth factor, anthrax edema toxin, and an Epac activator
Human microvascular endothelial cells (HMVEC) treated with vascular endothelial growth factor (VEGF), Antrhax Edema Toxin (ET), or the Epac activator, 8-pCPT-2'-O-Me-cAMP (8CPT); Human microvascular endothelial cells (HMVEC) were treated with VEGF alone or VEGF in combination with either the the Epa...
ORGANISM(S): Homo sapiens 
2009-09-13 | E-GEOD-17777 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cells treated with Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers
We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours Experiment Overall Design: Three experimental conditions with two biological replicates for the control condition corresponding to untreated HUVEC monolayer. RNA were extr...
ORGANISM(S): Homo sapiens 
2010-01-29 | E-GEOD-12131 | biostudies-arrayexpress
TranscriptomicsAnthrax Lethal Toxin-Inducd Gene Expression Changes in Mouse Lung
Enhanced susceptibility of A/J mice to death by systemic anthrax lethal toxin (LeTx) administration compared to the C57BL/6 strain was observed. In this study we investigated whether systemic exposure of mice to LeTx would induce gene expression changes associated with vascular/capillary leakage in ...
ORGANISM(S): Mus musculus 
2011-09-06 | E-GEOD-28554 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine macrophage-like RAW 264.7 cells treated with EdTx, protective antigen, or LPS for different length of time to examine the effect of EdTx on global transcriptional profiles.
Edema toxin (EdTx), which is a combination of edema factor and a binding moiety (protective antigen), is produced by Bacillus anthracis, the etiological agent of anthrax. EdTx is an adenylyl cyclase enzyme that converts adenosine triphosphate to adenosine-3',5'-monophosphate, resulting in interstiti...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4712 | biostudies-arrayexpress
TranscriptomicsBacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocyte.
Anthrax lethal toxin directly targets human peripheral monocytes and causes multiple aberrant gene responses that would be expected to result in defects in human monocyteM-bM-^@M-^Ys normal signaling transduction pathways and nction. This study provides further insights into the mechanisms associate...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-34407 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow derived macrophages (BMDM) treated with anthrax edema toxin (ET)
Bacillus anthracis, the causative agent of anthrax, secretes three toxin proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA is a transporter of LF and EF into host cells by receptor-mediated endocytosis. LF is a metalloprotease that cleaves mitogen-activated protein kin...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9184 | biostudies-arrayexpress
ProteomicsDiscovery of Mouse Spleen Signaling Responses to Anthrax using Label-Free Quantitative Phosphoproteomics via Mass Spectrometry
From article abstract: Inhalational anthrax is caused by spores of the bacterium Bacillus anthracis (B. anthracis), and is an extremely dangerous disease that can kill unvaccinated victims within 2 weeks. Modern antibiotic-based therapy can increase the survival rate to ~50%, but only if administere...
ORGANISM(S): Bacillus anthracis str. Sterne Mus musculus (Mouse) 
2017-03-22 | PXD006148 | Pride
Lc-msms Phosphoproteomics Mouse Label-free Spleen Anthrax 
TranscriptomicsBacillus cereus strain 31673
Comparative Genomic Hybridization. Analysis of genomic content of closely related Bacillus species. Refer to individual records for strain information. Refer to platform and individual sample records for experimental protocols.
ORGANISM(S): Bacillus anthracis str. Ames 
2010-06-05 | E-GEOD-568 | biostudies-arrayexpress
TranscriptomicsActivity of the Bacillus anthracis 20 kDa protective antigen component
Edema factor of anthrax binds to the protective antigen (PA83) which cleaves to PA63 and PA20. The role of PA20 was examined using highthroughput gene expression analysis of human peripheral blood mononuclear cells (PBMC) exposed to PA20. Keywords: Toxicity determination PBMC obtained from differe...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12533 | biostudies-arrayexpress
GenomicsMultiple stages of evolutionary change in anthrax toxin receptor expression in humans
Multiple stages of evolutionary change in anthrax toxin receptor expression in humans
PRJNA656946 | ENA
Sort   by:  
 Page size