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MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
TranscriptomicsA Highly Sensitive and Unbiased Approach for Elucidating Antibody Repertoires
Developing B lymphocytes undergo V(D)J recombination to assemble germline V, D, and J gene segments into exons that encode the antigen-binding variable region of immunoglobulin (Ig) heavy (H) and light (L) chains. IgH and IgL chains associate to form the B cell receptor (BCR), which upon antigen bi...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82126 | biostudies-arrayexpress
TranscriptomicsSAGE in Cultured Murine COC During Early Maturation
In cultured cumulus oocyte complexes (COC) FSH induces gene transcription required for germinal vesicle breakdown (GVBD). Experiments were performed to determine the critical period when gene transcription is required for GVBD and identify candidate mRNAs involved. Experiment I: murine COC were cult...
ORGANISM(S): Mus musculus 
2006-08-31 | E-GEOD-5568 | biostudies-arrayexpress
ProteomicsGeneration and utilization of a monoclonal antibody against hepatitis B virus core protein for a comprehensive interactome analysis
Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
2023-02-21 | PXD036961 | JPOST Repository
GenomicsAffinity maturation of antibody against membrane-bound GPCR molecules
Affinity maturation of antibody against membrane-bound GPCR molecules
PRJEB32492 | ENA
GenomicsRegulated somatic hypermutation enhances antibody affinity maturation
Regulated somatic hypermutation enhances antibody affinity maturation
PRJNA1211152 | ENA
GenomicsFAM72A promotes mutagenic repair during antibody maturation
FAM72A promotes mutagenic repair during antibody maturation
PRJNA761718 | ENA
TranscriptomicsEffects of in vitro maturation on oocyte gene expression
In vitro oocyte maturation (IVM) holds great promise as a tool for enhancing clinical treatment of infertility, enhancing availability of non human primates for development of disease models, and facilitating endangered species preservation. However, IVM outcomes have remained significantly below s...
ORGANISM(S): Macaca mulatta 
2009-05-20 | E-GEOD-11895 | biostudies-arrayexpress
UnknownExperimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.
Not available
S-EPMC6513101 | biostudies-literature
UnknownThe protein-protein interface evolution acts in a similar way to antibody affinity maturation.
Not available
S-EPMC2823529 | biostudies-literature
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