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TranscriptomicsMolecular diagnosis of T cell and/or antibody-mediated rejection in human kidney transplant biopsies
Histologic diagnosis of T cell-mediated rejection in kidney transplant biopsies has limited reproducibility because it is based on non-specific lesions using arbitrary rules that are subject to differing interpretations. We used microarray results from 403 indication biopsies previously given histol...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-36059 | biostudies-arrayexpress
ProteomicsIdentification of new immunomarkers of active antibody-mediated rejection through glomerular proteome analysis in kidney transplantation
Issues remain in the diagnosis of active antibody-mediated rejection (ABMR) in human kidney transplantation, as the hallmark criteria, the microcirculation inflammation scores and the C4d deposits, still lack reproducibility and sensitivity respectively. Using laser microdissection combined with mas...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD021852 | Pride
Proteomics Kidney transplantation Mass spectrometry Glomerulus Biomarker Antibody-mediated rejection 
TranscriptomicsAssessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes
Molecular phenotyping of biopsies affords opportunities for increased precision and improved disease classification to address the limitations of conventional histologic diagnostic systems. We applied archetypal analysis, an unsupervised method similar to cluster analysis, to microarray data from 12...
ORGANISM(S): Homo sapiens 
2017-07-10 | E-GEOD-98320 | biostudies-arrayexpress
ProteomicsOmics data integration analysis identified new biological insights into chronic antibody mediated rejection (CAMR).
INTRODUCTION: Chronic antibody-mediated rejection (CAMR) is currently the leading cause of long-term allograft loss, affecting approximately 50-60% of renal transplant recipients after a decade. Although in the last years many studies have performed to define clinical/histological characteristics an...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057746 | Pride
Proteomics Renal transplant Allograft loss Chronic antibody-mediated rejection 
TranscriptomicsMolecular characterization of chronic antibody mediated rejection in kidney transplantation (microRNA)
Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separate...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-51676 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of chronic antibody mediated rejection in kidney transplantation (mRNA)
Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separate...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-51675 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of chronic antibody mediated rejection in kidney transplantation (mRNA CD4)
Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separate...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-64261 | biostudies-arrayexpress
GenomicsDefining Relationships Among Tests for Kidney Transplant Antibody-Mediated Rejection
Defining Relationships Among Tests for Kidney Transplant Antibody-Mediated Rejection
PRJNA1216662 | ENA
GenomicsTranscriptomics of chronic antibody-mediated rejection
Transcriptomics of chronic antibody-mediated rejection
PRJNA1477039 | ENA
GenomicsTranscriptional changes in kidney allografts with histology of antibody-mediated rejection
Transcriptional changes in kidney allografts with histology of antibody-mediated rejection
PRJNA613023 | ENA
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