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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
Metabolomics1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug
1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in combination with multivariate statistical analyses to study the metabolic response of whole cells to the treatment with a hexacationic ruthenium metallaprism [1]6+ as potential anticancer drug. Human ovarian cancer cell...
2015-01-16 | MTBLS156 | MetaboLights
TranscriptomicsTranscriptome Analysis Predicts Clinical Outcome and Sensitivity to Anticancer Drugs of patients with a Pancreatic Adenocarcinoma
A major impediment to the effective treatment of patients with PDAC (Pancreatic Ductal Adenocarcinoma) is the molecular heterogeneity of the disease, which is reflected in an equally diverse pattern of clinical responses to therapy. We developed an efficient strategy in which PDAC samples from 17 co...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-55513 | biostudies-arrayexpress
GenomicsGut microbial metabolite butyrate improves anticancer therapy by regulating intracellular calcium homeostasis
Gut microbial metabolite butyrate improves anticancer therapy by regulating intracellular calcium homeostasis
PRJNA864053 | ENA
GenomicsOvercoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells.
Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells.
PRJNA414469 | ENA
TranscriptomicsGut microbial metabolite butyrate improves anticancer therapy by regulating intracellular calcium homeostasis
Gut microbiota are recognized to be important for anticancer therapy, yet the underlying mechanism is not clear. Herein, we demonstrate that gut microbial metabolite butyrate improves anticancer therapy efficacy by regulating intracellular calcium homeostasis. Butyrate metabolism is activated in hep...
ORGANISM(S): Homo sapiens 
2025-07-20 | GSE210156 | GEO
TranscriptomicsDifferential gene expression for A2780 human ovarian cancer cells when exposed to a new osmium-based anticancer agent
Platinum-based metallodrugs are the most widely used anticancer agents. Their reduced effectiveness after repeat dosing (resistance) constitutes a major clinical problem. In this experiment we study a potent organo-osmium compound with improved activity over cisplatin and no cross-resistance in plat...
ORGANISM(S): Homo sapiens 
2016-05-22 | E-MTAB-2758 | biostudies-arrayexpress
TranscriptomicsmiR-27b synergizes with anticancer drugs
Drug resistance, caused by complex and redundant mechanisms, is a major obstacle in cancer treatment, especially in liver and kidney cancers. Combinational therapy of miRNAs, which concurrently target multiple pathways, with anticancer drugs represent a new strategy to improve the drug response. By ...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-53872 | biostudies-arrayexpress
UnknownHydroxyethyl starch as an effective methotrexate carrier in anticancer therapy.
Not available
S-EPMC4186415 | biostudies-literature
TranscriptomicsmiR-27b synergizes with anticancer drugs
Drug resistance, caused by complex and redundant mechanisms, is a major obstacle in cancer treatment, especially in liver and kidney cancers. Combinational therapy of miRNAs, which concurrently target multiple pathways, with anticancer drugs represent a new strategy to improve the drug response. By ...
ORGANISM(S): Homo sapiens 
2014-01-07 | GSE53872 | GEO
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