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TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
ProteomicsTumor-derived CDC37 inhibits antigen cross-presentation in dendritic cells and impairs anti-tumor immunity in breast cancer
Tumor mutational burden (TMB), usually representing high immunogenicity, could not always predict treatment response of immune checkpoint blockade (ICB). Here, we showed that defective antigen cross-presentation in type 1 conventional dendritic cells (cDC1) was responsible for lacking tumor-specific...
ORGANISM(S): Homo Sapiens 
2025-10-17 | PXD069576 |
ProteomicsProteomic analysis of regulated dendritic cell endosomes reveals dynamic adaptation to antigen uptake and cross-presentation
MHC class I cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated aminopeptidase (IRAP). Reasoning that analysis of the IRAP proximal proteome may inform about dynamic remodeling of a key cross-presentation compartment during antigen uptake, we developed...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD067092 | Pride
Endosome Insulin-regulated aminopeptidase Proximity biotinylation Cross-presentation Dendritic cell 
GenomicsAntigen cross-presentation at single-cell resolution
Antigen cross-presentation at single-cell resolution
PRJNA1237285 | ENA
GenomicsDNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
PRJNA1211014 | ENA
TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose ...
ORGANISM(S): Mus musculus 
2009-06-19 | GSE15616 | GEO
ProteomicsEnhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease Cathepsin S
Cross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional APCs, including cancer-associated fibroblasts (CAFs) also possess this capacity. It is curre...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD029507 | Pride
Tumor immunology Non-professional antigen presentation Parallel reaction monitoring Stromal immunobiology 
TranscriptomicsAntigen cross-presentation at single-cell resolution
Antigen cross-presentation by dendritic cells (DCs) to CD8+ cytotoxic T cells (CTLs) is a key step in the immunological cascade. Although the overall sequence of events at DC synapses has been studied at the level of entire tissues, the molecular dynamics of cross-presentation, CTL activation and re...
ORGANISM(S): Mus musculus 
2026-03-16 | GSE292150 | GEO
TranscriptomicsDNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
Innate immune receptors often induce activation of conventional dendritic cells (cDCs) and enhance antigen (cross-)presentation, favouring immune responses. DNGR-1 (CLEC9A), a receptor expressed by type 1 cDCs (cDC1s) and implicated in immune responses to viruses and cancer, recognises F-actin expos...
ORGANISM(S): Mus musculus 
2025-10-28 | GSE287030 | GEO
GenomicsThe pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
PRJNA1156795 | ENA
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