Sort   by:  
 Page size 
MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
ProteomicsCross-linking of the human MHC-I peptide-loading complex
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum (ER), essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the ER with loading and editing of major histocompatibility complex class I mol...
ORGANISM(S): Homo sapiens (Human) 
2017-11-07 | PXD007928 | Pride
Cross-linking Cryo-electron microscopy Structure Mhc-i peptide-loading complex 
TranscriptomicsMechanical loading and gene expression - Microarray study
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | E-GEOD-50707 | biostudies-arrayexpress
ProteomicsViral immune evasions differentially impact cell surface presentation of MHC I allomorphs already at the peptide-loading complex
The transporter associated with antigen processing (TAP) translocates peptides from the cytosol into the endoplasmic reticulum (ER) where they are loaded onto major histocompatibility class I (MHC I) molecules. Stable peptide-MHC I complexes travel to the cell surface and present their antigenic car...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027408 | Pride
Er quality control Major histocompatibility complex class i Mass spectrometry Mhc i biogenesis Viral immune evasion Peptide-loading complex 
TranscriptomicsEvidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge
Cohesin is a multisubunit complex that mediates sister-chromatid cohesion. Its Smc1 and Smc3 subunits possess ABC-like ATPases at one end of 50 nm long coiled coils. At the other ends are pseudosymmetrical hinge domains that interact to create V-shaped Smc1/Smc3 heterodimers. N- and C-terminal domai...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-4827 | biostudies-arrayexpress
TranscriptomicsSmall RNA loading licenses Argonaute for assembly into a transcriptional silencing complex
We analyzed the small RNAs bound to the fission yeast RITS and ARC complexes, and to Ago1 in wild-type and ARC mutant cells, to gain insight into the molecular role of ARC. We found that ARC contains longer heterochromatic siRNAs than RITS, and that ARC subunit Arb1 is required for loading small RNA...
ORGANISM(S): Schizosaccharomyces pombe 
2015-03-01 | E-GEOD-65223 | biostudies-arrayexpress
ProteomicsCT26 Proteome and Immunopeptidome treated with Ionizing Radiation
This project explored the relationship between ionizing radiation and antigen presentation using both proteomic and immunopeptidomics methodologies. We investigated the radiation-specific changes which occur in the colorectal tumor cell proteome associated with changes in dose and time after irradia...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-04 | PXD032003 | Pride
Interferon signaling Ligandomics Mhc Ionizing radiation Immunopeptidomics 
UnknownLight control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking.
Not available
S-EPMC8010092 | biostudies-literature
GenomicsCcp1 homodimer mediates chromatin integrity by antagonizing CENP-A loading
CENP-A is a centromere-specific histone 3 variant essential for centromere specification. CENP-A partially replaces canonical histone H3 at the centromeres. How the particular CENP-A/H3 ratio at centromeres is precisely maintained is unknown. It also remains unclear how CENP-A is excluded from non-c...
ORGANISM(S): Schizosaccharomyces pombe 
2016-08-04 | E-GEOD-85166 | biostudies-arrayexpress
ProteomicsOptimizing High-Throughput Shotgun Immunoproteomics for Antigen Identification
Identification of individual proteins (i.e., antigens) which initiate and/or perpetuate adaptive immune responses has potential to greatly impact pre-clinical and clinical work across numerous fields. To date, however, the methodologies available to identify antigens responsible for driving adaptive...
ORGANISM(S): Bos taurus (Bovine) 
2023-04-18 | PXD038761 | Pride
Tandem-mass tag labeling Antigen identification Xenogeneic biomaterials Affinity chromatography Humoral immune response Proteomics 
Sort   by:  
 Page size