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MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
TranscriptomicsTranscription profiling of mouse dendritic subsets in vivo
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6259 | biostudies-arrayexpress
TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
GenomicsHippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity
Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity
PRJNA1063716 | ENA
TranscriptomicsImproved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
Attenuated poxviruses are safe and capable to express foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune respon...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-26239 | biostudies-arrayexpress
ProteomicsHLA-DP(84Gly) constitutively presents endogenous peptides generated by the class I antigen processing pathway
Classical antigen processing/presentation mechanisms lead to the presentation of antigenic peptides derived from endogenous and exogenous sources for MHC class I and class II molecules, respectively. We show here that, unlike other class II, prevalent HLA-DP molecules whose chains encode Gly84 (DP8...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080228 | MassIVE
TranscriptomicsGene expression analysis of molecules with known function in HLA class II antigen processing and presentation in hematopoietic and (cytokine pre-treated) non-hematopoietic cells.
Gene expression analysis of molecules with known function in HLA class II antigen processing and presentation. Various hematopoietic cell types and (cytokine pre-treated) non-hematopoietic cells that are targeted in Graft-versus-Leukemia reactivity and Graft-versus-Host Disease were collected. Expre...
ORGANISM(S): Homo sapiens 
2012-06-18 | E-GEOD-38798 | biostudies-arrayexpress
GenomicsImpaired HLA Class 1 Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
Impaired HLA Class 1 Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
PRJNA412283 | ENA
GenomicsImpaired HLA Class 1 Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
Impaired HLA Class 1 Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
PRJNA412284 | ENA
ProteomicsDeleterious knock-outs in the HLA class I antigen processing and presentation machinery induce distinct changes in the immunopeptidome
The human leukocyte antigen (HLA) processing and presentation machinery (APPM) is altered in various diseases and in response to drug treatments. Defects in the machinery may change presentation levels or alter the repertoire of presented peptides, globally or in an HLA allele restricted manner, wit...
ORGANISM(S): Homo sapiens (Human) 
2025-04-04 | PXD056426 | Pride
Immunopeptidomics Antigen presentation 
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