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TranscriptomicsP. falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. PfEMP1 also mediates sequestration of infected ...
ORGANISM(S): Plasmodium falciparum 
2010-05-06 | E-GEOD-17029 | biostudies-arrayexpress
ProteomicsAntibodies to protozoan variable surface antigens induce antigenic variation
The genomes of most protozoa encode families of variant surface antigens, whose mutually exclusive changes in expression allow parasitic microorganisms to evade the host immune response1. It is widely assumed that antigenic variation in protozoan parasites is accomplished by the spontaneous appearan...
ORGANISM(S): Giardia lamblia ATCC 50803 
2023-05-10 | PXD031141 | Pride
Exosomes Microvesicles Giardia Antigenic variation 
TranscriptomicsAntigenic variation in recrudescent Plasmodium chabaudi infection
The aim of this study is to look at antigenic variation in recrudescent Plasmodium chabaudi infections and to identify the genes, if any, which allow the parasite to avoid the acquired immune response during recrudescence. This has been done in collaboration with Jean Langhorne at NIMR whose group p...
ORGANISM(S): Plasmodium chabaudi 
2014-01-21 | E-ERAD-206 | biostudies-arrayexpress
TranscriptomicsResponse of peripheral blood mononuclear cells from patients with allergy to cat and silver birch wood derived antigenic peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 2 donors with allergy. The c...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72373 | biostudies-arrayexpress
ProteomicsThe Trypanosoma cruzi Antigen and Epitope Atlas: fine characterization of antibody specificities in human Chagas Disease patients across human populations
These assays represent antibody-binding assays to analyze seroprevalence of antigens and epitopes at the individual level and also to perform fine epitope mapping characterizations. In this screening 392,299 peptides derived from reactive (antigenic) regions of Trypanosoma cruzi proteins were displa...
ORGANISM(S): Homo sapiens 
2022-08-20 | E-MTAB-11655 | biostudies-arrayexpress
ProteomicsUMSBP2 is chromatin remodeler that functions in regulation of gene expression and suppression of antigenic variation in trypanosomes
Universal Minicircle Sequence binding proteins (UMSBPs) are CCHC-type zinc-finger proteins that bind the single-stranded G-rich UMS sequence, conserved at the replication origins of minicircles in the kinetoplast DNA, the mitochondrial genome of trypanosomatids. Trypanosoma brucei UMSBP2 has been re...
ORGANISM(S): Trypanosoma brucei 
2023-07-20 | PXD030439 | Pride
Trypanosomes Antigenic variation Gene expression Umsbp Chromatin remodeling 
GenomicsAntigenic cartography of immune responses to Recombinant DBLα tags from Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
Antigenic cartography of immune responses to Recombinant DBLα tags from Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
PRJEB32811 | ENA
ProteomicsGeneration of SARS-CoV-2 S1 spike glycoprotein putative antigenic epitopes in vitro by intracellular aminopeptidases
Presentation of antigenic peptides by MHCI is central to cellular immune responses against viral pathogens. While adaptive immune responses versus SARS-CoV-2 can be of critical importance to both recovery and vaccine efficacy, how protein antigens from this pathogen are processed inside the cell to ...
ORGANISM(S): SARS bat coronavirus 
2021-11-25 | PXD019901 | Pride
Immune system Peptide Enzyme Sars Aminopeptidase Major histocompatibility molecules Antigen Antigen processing and presentation Epitope Adaptive immunity Lc-ms/ms 
ProteomicsA DOT1B/RH2 protein complex is involved in R-loop processing, genomic integrity and antigenic variation in Trypanosoma brucei
The parasite Trypanosoma brucei periodically changes the expression of protective variant surface glycoproteins (VSGs) to evade its host’s immune system in a process known as antigenic variation. One route to change VSG expression is the transcriptional activation of a previously silent VSG expressi...
ORGANISM(S): Trypanosoma brucei 
2021-10-25 | PXD028588 | Pride
Lc/ms-ms 
ProteomicsNanoparticle-loaded antigenic components
e dissolved eight antigenic nanoparticles to release their loaded components and assayed the protein species in them
ORGANISM(S): Homo Sapiens 
PXD052576 |
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