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MetabolomicsOpen source discovery of starting points for next generation chemoprotective antimalarial drugs (Biofocus 1)
Not available
ORGANISM(S): Homo sapiens 
ST001074 | MetabolomicsWorkbench
ProteomicsValidation of Solvent Proteome Profiling for Antimalarial Drug Target Deconvolution
Malaria remains a global health threat, with rising drug resistance accelerating the urgent need for new therapeutics. Target elucidation is a critical step in antimalarial drug discovery, enabling a deeper understanding of the molecular mechanisms of action of both existing and novel compounds. Thi...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-11-25 | PXD071156 | Pride
Malaria  plasmodium falciparum  solvent-induced proteome profiling (spp)  drug target deconvolution  orbitrap astral ms  antimalarial compounds 
ProteomicsA novel antimalarial agent that inhibits protein synthesis in Plasmodium falciparum
Drug resistance to nearly all antimalarials following their rollout underscores the need for novel chemotypes with novel mode of action to replenish the antimalarial drug-development pipeline. We identified a novel class of compounds in the antimalarial armory. Compound 31, characterized by a hydrox...
ORGANISM(S): Plasmodium falciparum NF54 
2025-12-08 | PXD065399 | Pride
Drug discovery Drug resistance Hydroxy benzamides Antimalarial 
TranscriptomicsImaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
Most malaria drug development focuses on parasite stages detected in red-blood cells even though to achieve eradication next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial approach to a set of >4,000 commercially availabl...
ORGANISM(S): Plasmodium falciparum 
2011-10-31 | E-GEOD-32485 | biostudies-arrayexpress
UnknownPrioritization of Molecular Targets for Antimalarial Drug Discovery.
Not available
S-EPMC8608365 | biostudies-literature
ProteomicsMulti-omics analysis demonstrates unique mode of action of a potent new antimalarial compound, JPC-3210, against Plasmodium falciparum
The increasing incidence of antimalarial drug resistance to the first-line artemisinins, and their combination partner drugs, underpins an urgent need for new antimalarial drugs, ideally with a novel mechanism of action. The recently developed 2-aminomethylphenol, JPC-3210, (MMV 892646) is an erythr...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2019-12-20 | PXD013539 | Pride
Antimalarial drug discovery Proteomics Mechanism of action Metabolomics 2-aminomethylphenol 
TranscriptomicsPlasmodium falciparum treated with cyclohexylamine
Transcriptional profiling of P. falciparum cultures treated with cyclohexylamine over time (18, 25 and 30 hours post invasion) A control experiment was also set up in which P. falciparum was not treated with cyclohexylamine, and samples were taken at 18, 25 and 30 h post invasion). Background Plasm...
ORGANISM(S): Plasmodium falciparum 
2010-04-19 | E-GEOD-18075 | biostudies-arrayexpress
UnknownNew targets for antimalarial drug discovery.
Not available
S-EPMC9934905 | biostudies-literature
TranscriptomicsAnticancer properties of distinct antimalaria drug classes
Background: Antimalarials have anticancer potential. Results: We have systematically tested five distinct antimalaria drugs in a panel of cancer cell lines. Conclusion: Three antimalarial classes display potent antiproliferative activity, and their potency is correlated with cancer cell gene expre...
ORGANISM(S): Homo sapiens 
2013-10-26 | E-GEOD-51739 | biostudies-arrayexpress
UnknownAccelerating Antimalarial Drug Discovery with a New High-Throughput Screen for Fast-Killing Compounds.
Not available
S-EPMC11650643 | biostudies-literature
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