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ProteomicsHuman thyroid neoplasms LC-MS/MS analysis
The study aimes to evaluate the neoplasm proteomic changes in benign follicular adenoma versus malignant follicular variant of papillary thyroid carcinoma. Tumor and non-tumor adjacent samples were analyzed by liquid nano-chromatography mass spectrometry and protein abundance was evaluated by label ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD004322 | Pride
Human Thyroid Lc-ms/ms 
ProteomicsMouse early diabetic nephropathy LC-MS/MS analysis
The present study aims to evaluate the alterations induced by type I diabetes and the associated hyperglycemia on the proteome of renal tissue using a transgenic experimental animal model. Diabetic and non-diabetic kidney samples were analyzed by liquid nano-chromatography mass spectrometry and p...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-24 | PXD018053 | Pride
Mouse Diabetes Kidney Lc-ms/ms 
ProteomicsAlteration of DAMPs and regulated cell death under hyperlipidemic stress
We hypothesize that DAMPs and non-apoptotic regulated cell death processes are critical players of artery plaque progression with inadequate response to lipid-lowering treatment. Using high performant LC-MS/MS proteomic analysis we aim to uncover the silent mechanisms that govern the existing residu...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2022-02-22 | PXD026379 | Pride
Regulated cell death Proteomics Mass spectrometry Damps 
ProteomicsCoronary alarmins as residual risk markers of atherosclerosis under hypolipidemic therapy
Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. A more recent therapy, with encouraging results, to regul...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2022-10-03 | PXD035692 | Pride
Atherosclerosis Proteomics Residual risk Mass spectrometry Alarmins 
ProteomicsProteomic Analysis of Estrogen Mediated Enhancement of MSC-Induced Angiogenesis in vivo
Therapeutic use of mesangial stem cells (MSCs) for tissue repair, including heart, has great potential. MSCs from multiple sources, including those derived from human umbilical matrix, namely Wharton's jelly, may serve as a resourceful candidate. Even after more than a decade, low engraftment effica...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026380 | Pride
Proteomics Angiogeneis Msc 
ProteomicsMechanism of 17-β Estradiol Stimulated Integration of Human Mesenchymal Stem Cells in Heart Tissue
Scarcity of gender specific donor hearts highlights the importance of mesenchymal stem cells (MSCs) as a therapeutic tool for heart repair. However, inefficient incorporation, retention, and activity of MSCs in cardiac tissue remains an obstacle. Since surge in follicular estradiol (μmolar-range) tr...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD011742 | Pride
Women Estrogen Stem cells Heart repair Heart disease Gender Tissue remodeling 
ProteomicsDiabetic foot syndrome plasma proteomic analysis
We explored the contribution of Damage-Associated Molecular Pattern (DAMP) proteins and the specific receptor Toll-like receptor 4 (TLR4) to the inflammatory and vascular dysfunction underlying DFS progression. Clinical, hematological, and proteomic analyses were performed on plasma of patients wit...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD073507 | Pride
Dfs Damp Biomarker 
ProteomicsExosome proteomics reveals the deregulation of coagulation, complement and lipid metabolism proteins in gestational diabetes mellitus
Exosomes are the smallest extracellular vesicles which are released during pregnancy by the placenta, umbilical cord, amniotic fluid and various cell membranes in the extracellular space. The content of exosomes during pregnancy is strongly related to various conditions such as gestational diabetes ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-22 | PXD035673 | Pride
Proteomics Lipid metabolism Mass spectrometry Prothrombotic factors Complement system Gestational diabetes mellitus Platelet activation 
ProteomicsProteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model
Background: Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing will become a clinical problem and will affect the patient's qua...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-29 | PXD016135 | Pride
Ms-based proteomics Titanium implant Growth factors Bone healing 
ProteomicsShort-term blockade of pro-inflammatory alarmin S100A9 fa-vorably modulates left ventricle proteome and related signaling pathways involved in post – myocardial infarction recovery
Prognosis after myocardial infarction (MI) varies greatly depending of the extent of damaged area and the management of biological processes during recovery. Reportedly, the inhibition of the pro-inflammatory S100A9 reduces myocardial damage after MI. We hypothesize that S100A9 blockade induces chan...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD033683 | Pride
Hypertrophy Apoptosis Cardiac repair S100a9 Myocardial infarction 
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