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ProteomicsMechanism of RPA phosphocode priming and tuning by Cdk1/Wee1 signaling circuit
Replication protein A (RPA) is a heterotrimeric single-strand DNA binding protein that is integral to DNA metabolism. Segregation of RPA functions in response to DNA damage is fine-tuned by hyperphosphorylation of the RPA32 subunit that is dependent on Cyclin-dependent kinase (Cdk)-mediated priming ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD068080 | Pride
Rpa domain configurations Rpa phosphorylation Cdk1 Wee1 Cell cycle 
ProteomicsMechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs). The DSBs are resected to yield single-stranded DNA (ssDNA) that are coated by Replication Protein A (RPA). Rad51 is a recombinase and catalyzes strand invasion and the search for homology. However, it binds to ssDNA with lower ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-28 | PXD065573 | Pride
Cross-linking Lc-msms 
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