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ProteomicsIFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human and mouse models, we demonstrate that IFITM3 promotes MyD88-dependent, TLR-mediated IL-6 production following exposure...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-28 | PXD035254 | Pride
Viral pathogenesis Ip-mass spec Silac 
ProteomicsInvasion preferences suggest a possible role for Plasmodium falciparum parasites in the expansion of Duffy negativity in West and Central Africa
Duffy antigen receptor for chemokines (DARC) is the primary red blood cell (RBC) receptor for invasion of human RBCs by Plasmodium vivax and Plasmodium knowlesi merozoites. By contrast, Plasmodium falciparum parasites, which are the dominant cause of malaria in West and Central Africa, use multiple ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD065766 | Pride
Plasma membrane profiling Rbc surface proteome Duffy-negative rbc surface proteome Tmt 
ProteomicsGenome-Wide CRISPR/Cas9 Screen shows that inhibiting GET4 is neuroprotective and increases mitochondrial-endoplasmic reticulum contact sites
Organelles form contacts between each other allowing for transfer of molecules and signals. Mitochondria-ER Contact sites (MERCS) are lengths of the Mitochondria and ER membrane which come together but do not fuse. They have been implicated in many diseases, including neurodegenerative, metabolic, a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042710 | Pride
Mitochondrial-er contact site Neuroprotection Ip-mass spectrometry 
ProteomicsCompounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Enhancing the removal of aggregate-prone toxic proteins is a rational therapeutic strategy for a number of neurodegenerative diseases, especially Huntington’s disease and various spinocerebellar ataxias. Ideally, such approaches should preferentially clear the mutant/misfolded species, while having ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-15 | PXD034712 | Pride
Beclin 1 Atpase Smer28 Autophagy Ubiquitin-proteasome system Neurodegeneration Vcp Protein quality control 
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