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UnknownThe autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection.
Not available
S-EPMC9596692 | biostudies-literature
UnknownSMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta.
Not available
S-EPMC9140127 | biostudies-literature
ProteomicsVCP D1 ATPase activation enhances both autophagic and proteasomal neurotoxic protein clearance
Autophagy upregulation enhances the clearance of various neurotoxic proteins and ameliorates their toxicities in disease models. Thus, autophagy activators may have therapeutic utility. Here, we have identified the essential protein VCP/p97 as a target of the autophagy-inducing molecule SMER28, prov...
ORGANISM(S): Escherichia coli 
2022-07-15 | PXD027750 | Pride
Beclin 1 Atpase Smer28 Autophagy Ubiquitin-proteasome system Limited proteolysis Lip-ms Neurodegeneration Vcp Protein quality control 
ProteomicsCompounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Enhancing the removal of aggregate-prone toxic proteins is a rational therapeutic strategy for a number of neurodegenerative diseases, especially Huntington’s disease and various spinocerebellar ataxias. Ideally, such approaches should preferentially clear the mutant/misfolded species, while having ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-15 | PXD034712 | Pride
Beclin 1 Atpase Smer28 Autophagy Ubiquitin-proteasome system Neurodegeneration Vcp Protein quality control 
TranscriptomicsDrug Discovery For Diamond Blackfan Anemia Using Reprogrammed Hematopoietic Progenitors
Diamond-Blackfan anemia (DBA) is a congenital disorder characterized by the failure of erythroid progenitor differentiation, severely curtailing red blood cell production. Because many DBA patients fail to respond to corticosteroid therapy, there is considerable need for therapeutics for this disord...
ORGANISM(S): Homo sapiens 
2017-01-01 | GSE90940 | GEO
UnknownA small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
Not available
S-EPMC3101026 | biostudies-literature
UnknownDrug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors.
Not available
S-EPMC5501179 | biostudies-literature
GenomicsHomo sapiens
Drug Discovery For Diamond Blackfan Anemia Using Reprogrammed Hematopoietic Progenitors
PRJNA356410 | ENA
UnknownA Review of Diamond-Blackfan Anemia: Current Evidence on Involved Genes and Treatment Modalities.
Not available
S-EPMC7515741 | biostudies-literature
UnknownCompounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Not available
S-EPMC9288506 | biostudies-literature
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