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ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
TranscriptomicsAortic arch profiling of Apoe knockout mice
Aortic arch profiling of Apoe-/- mice fed a high fat diet (HFD, Harlan Teklad 88137, 21% fat, 0.15% cholesterol) starting at 8 weeks of age for 8, 16, and 24 weeks. B6 mice fed HFD for 16 weeks starting at 8 weeks of age were used as controls. Apoe-/- mice were fed a high fat diet (HFD, Harlan Tekl...
ORGANISM(S): Mus musculus 
2010-06-22 | E-GEOD-18443 | biostudies-arrayexpress
TranscriptomicsAortic arch profiling of Ldlr knockout mice with human CETP transgene
Aortic arch profiling of Ldlr-/- huCETP transgenic mice fed a low fat, cholesterol-containing western diet (LFWD, 9% fat, 0.15% cholesterol) starting at 8 weeks of age for 4, 8, 12, and 16 weeks. Ldlr-/- huCETP transgenic mice were fed a low fat, cholesterol-containing western diet (LFWD, 9% fat, ...
ORGANISM(S): Mus musculus 
2010-06-22 | E-GEOD-18442 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of Sus scrofa endothelial cells isolated from the athero-protective descending thoracic aorta and the athero-susceptible aortic arch
This study investigates the regional expression profiles of microRNAs (miRNAs) in endothelial cells isolated from the athero-protective descending thoracic aorta (DT) and from the athero-susceptible aortic arch (AA) in a swine model. Seven 2-channel assays comparing DT samples to AA samples were per...
ORGANISM(S): Sus scrofa 
2010-07-16 | E-CBIL-46 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing experiment of aortic arch and root samples from mice with rHDL and PS@rHDL treatment
The experiment was performed by using Apoe-/- mice fed on a high-fat, high-cholesterol diet (Western diet, WD) for either 6 weeks. The samples were collected from aortic arch and root of two different groups of mice: one treated with rHDL (reconstituted HDL nanoparticles), and the other with PS@rHDL...
ORGANISM(S): Mus musculus 
2024-08-08 | E-MTAB-14252 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig aortic endothelium taken from regions of disturbed and undisturbed flow
This study investigates the role of endothelial cell (EC) gene expression in the focal origin of atherosclerosis, particularly in response to local hemodynamics. Differential gene expression was profiled in EC isolated from athero-susceptible and athero-protected regions of the normal pig aorta. Spe...
ORGANISM(S): Sus scrofa 
2006-07-21 | E-CBIL-17 | biostudies-arrayexpress
TranscriptomicsGene expression data from Ldlr-/-, Apob100/100, Mttp flox/flox Mx1-Cre mice at different stages of atherosclerosis development
Gene expression profiles from the aortic arch of Ldlr-/-Apob100/100 Mttpflox/flox Mx1-Cre mice at different stages of atherosclerosis development Total RNAs from the aortic arch were collected at different time points during atherosclerosis development (10, 20, 30, 40, 50, and 60 weeks of age), 4-7 ...
ORGANISM(S): Mus musculus 
2012-06-07 | E-GEOD-38574 | biostudies-arrayexpress
TranscriptomicsIdentification and validation of causal genes for atherosclerosis in mice
Identification of causal genes for atherosclerosis in a segregating mouse population and validation via single-gene knockout and plaque progression mouse models. This SuperSeries is composed of the following subset Series: GSE18442: Aortic arch profiling of Ldlr knockout mice with human CETP transg...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-18479 | biostudies-arrayexpress
TranscriptomicsAortic valve transcriptome in CHIP, non-CHIP and non-calcific controls.
The aim of the present study was to gain insights on the pathological process of Calcific Aortic Valve Disease in CHIP carriers. To uncover molecular pathways that could link CHIP to CAVD, we exanimated the aortic valve transcriptome from CHIP, non-CHIP patients, or non-calcific controls with RNAseq...
ORGANISM(S): Homo sapiens 
2022-08-02 | E-MTAB-11354 | biostudies-arrayexpress
UnknownOpen aortic arch surgery-how we do it.
Not available
S-EPMC10713500 | biostudies-literature
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