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ProteomicsThe extracellular matrix landscape identifies different etiologies behind bicuspid and tricuspid aortic valve degeneration
The molecular basis of aortic valve degeneration (AVD) is unclear. The extracellular matrix (ECM) of the valve is in dynamic reciprocity with its surrounding microenvironment and contains molecular traits of the pathophysiological processes. We compared abundances of ECM proteins from excised valve ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-03 | PXD025002 | Pride
Ecm Lc-ms/ms Human Aortic valve degeneration Extracellular matrix 
TranscriptomicsTranscription profiling of aorta from mice underexpressing Fibulin-4 to investigate its role in elastic fibre assembly and cardio-vasuclar disease
Extracellular elastic fibres apply structure and mechanical elasticity to organs such as large arteries, lungs and skin 1. Elastic fibres are assembled through polymerization of tropoelastin monomers and loss of elastin is associated with aneurysmal degeneration of the aorta 2. The Fibulins are a ...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-840 | biostudies-arrayexpress
ProteomicsADAMTS7, a target in atherosclerosis, cooperates with homolog ADAMTS12 to protect against myxomatous valve degeneration
The metalloprotease ADAMTS7, a drug target in atherosclerosis and vascular restenosis, is thought to have no relevant physiological role in the cardiovascular system. However, potential cooperation with its close homolog, ADAMTS12, that may mask such a role remains unexplored. The objective of the p...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-07 | PXD055550 | Pride
Metalloproteinase Hypertrophy Chondroitin sulfate Heart valve Fibrosis Adamts Regurgitation Extracellular matrix Myxomatous valve 
ProteomicsCorrelation between aortic valve protein levels and vector flow mapping of wall shear stress and oscillatory shear index in patients supported with continuous-flow left ventricular assist devices
Continuous-flow left ventricular assist devices commonly lead to aortic regurgitation, which results in decreased pump efficiency and worsening heart failure. We hypothesized that non-physiological wall shear stress and oscillatory shear index alter the abundance of structural proteins in aortic val...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-23 | MSV000086941 | MassIVE
UnknownNative Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation.
Not available
S-EPMC8542078 | biostudies-literature
UnknownSerum lipoprotein(a) and bioprosthetic aortic valve degeneration.
Not available
S-EPMC10229296 | biostudies-literature
UnknownDetection and Prediction of Bioprosthetic Aortic Valve Degeneration.
Not available
S-EPMC6424589 | biostudies-literature
UnknownUntreatable Severe Structural Degeneration of a Transcatheter Aortic Heart Valve.
Not available
S-EPMC8290901 | biostudies-literature
UnknownTranscatheter aortic valve implantation with a novel pre-packaged self-expandable dry-tissue transcatheter aortic valve: a case report.
Not available
S-EPMC7954253 | biostudies-literature
UnknownIn-Series Transcatheter Aortic Valve Replacement-in-Transcatheter Aortic Valve Replacement: ACURATE neo Transcatheter Heart Valve Degeneration Successfully Managed with Myval, Avoiding Coronary Flow Obstruction-A Case Report.
Not available
S-EPMC10512008 | biostudies-literature
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