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MetabolomicsThe apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections.
Not available
ORGANISM(S): Toxoplasma gondii 
ST002051 | MetabolomicsWorkbench
MetabolomicsThe Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here we used TurboID and genome engineering to identify apicop...

2024-01-15 | MTBLS7060 | MetaboLights
GenomicsGenome assembly of the Apicomplexan parasite Hepatocystis
Genome assembly of the Apicomplexan parasite Hepatocystis from a Piliocolobus blood sample
PRJEB32891 | ENA
ProteomicsDe novo mapping of the apicomplexan Ca2+-responsive phosphoproteome
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca2+ signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specific cellular processes governing the transition bet...
ORGANISM(S): Toxoplasma gondii RH 
2022-10-15 | PXD033765 | Pride
Toxoplasma Parasite Calcium signaling Phosphoproteomics Apicomplexan Systems biology 
TranscriptomicsTetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum
Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, th...
ORGANISM(S): Plasmodium falciparum 
2010-07-01 | E-GEOD-5267 | biostudies-arrayexpress
ProteomicsDe novo mapping of the apicomplexan Ca2+-responsive proteome: temperature range thermal profiling experiment
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca2+ signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specific cellular processes governing the transition bet...
ORGANISM(S): Toxoplasma gondii RH 
2022-10-15 | PXD033713 | Pride
Toxoplasma Parasite Calcium signaling Cetsa Tpp Apicomplexan Systems biology Thermal profiling 
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
ProteomicsDe novo mapping of the apicomplexan Ca2+-responsive phosphoproteome
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca2+ signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specific cellular processes governing the transition bet...
ORGANISM(S): Toxoplasma gondii RH 
2023-08-21 | PXD033738 | Pride
Toxoplasma Tmtpro Parasite Systems biology Phosphoproteomics Tmt16plex Quantitative proteomics 
ProteomicsDe novo mapping of the apicomplexan Ca2+-responsive proteome: concentration range thermal profiling experiment 2
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca2+ signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specific cellular processes governing the transition bet...
ORGANISM(S): Toxoplasma gondii RH 
2022-10-15 | PXD033650 | Pride
Toxoplasma Thermal proteome profiling Proteomics Parasite Calcium signaling Cetsa Tpp Apicomplexan Systems biology 
GenomicsLifecycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum
Lifecycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum
PRJNA530692 | ENA
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