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ProteomicsProteomic analysis of APLN, APLN-DM-expressing cells
Dysregulated APLN have been widely reported in tumorigenesis, yet the role of the proteolytic cleavage of APLN precursor proAPLN in oncogenesis is not known. Here, we identify Furin the unique proprotein convertase able to cleave proAPLN in cancer cells. We generated for preclinical development APL...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-15 | PXD045256 | Pride
Apln Colon cancer Apln-dm Quantitative proteome 
TranscriptomicsApelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD. We identified the loss of APLN expression in lymphed...
ORGANISM(S): Homo sapiens 
2023-10-20 | E-MTAB-13381 | biostudies-arrayexpress
GenomicsTranscriptomes of crypt intestinal epithelial cells from Apln-/- mice
Transcriptomes of crypt intestinal epithelial cells from Apln-/- mice
PRJNA737406 | ENA
UnknownGenetic targeting of sprouting angiogenesis using Apln-CreER.
Not available
S-EPMC4309445 | biostudies-literature
UnknownHigh APLN Expression Predicts Poor Prognosis for Glioma Patients.
Not available
S-EPMC9526648 | biostudies-literature
UnknownAPLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target.
Not available
S-EPMC6691573 | biostudies-literature
TranscriptomicsTranscriptomes of crypt intestinal epithelial cells from Apln-/- mice
We used bulk RNAseq to analyze crypt intestinal epithelial gene expression changes between wild-type and Apln-/- adult mice
ORGANISM(S): Mus musculus 
2022-03-29 | GSE178110 | GEO
UnknownCREB5 promotes nodal metastasis of cervical cancer by regulation of APLN-induced lymphangiogenesis.
Not available
S-EPMC12559322 | biostudies-literature
UnknownApelin (APLN) is a biomarker contributing to the diagnosis and prognosis of hepatocellular carcinoma.
Not available
S-EPMC11371925 | biostudies-literature
TranscriptomicsTargeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models
Type 2 diabetes mellitus is one of the most prevalent metabolic diseases affecting multiple organs, including reproductive disorders in male diabetic patients. However, the molecular mechanisms that contribute to spermatogenesis dysfunction in diabetic patients have not yet been fully elucidated. He...
ORGANISM(S): Homo sapiens Mus musculus 
2022-10-27 | GSE179080 | GEO
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