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ProteomicsProteomic analysis of APLN, APLN-DM-expressing cells
Dysregulated APLN have been widely reported in tumorigenesis, yet the role of the proteolytic cleavage of APLN precursor proAPLN in oncogenesis is not known. Here, we identify Furin the unique proprotein convertase able to cleave proAPLN in cancer cells. We generated for preclinical development APL...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-15 | PXD045256 | Pride
Apln Colon cancer Apln-dm Quantitative proteome 
TranscriptomicsChIP-chip of BMP2 or control treated human pulmonary artery endothelial cells with anti-beta-catenin or anti-ppar-gamma antibodies on promoter regions
Reduced bone morphogenetic protein receptor (BMPR)2 expression in patients with pulmonary arterial (PA) hypertension (PAH), can impair PA endothelial cell (EC) function. We now characterize, in human PAECs, a novel BMPR2-mediated transcriptionally active complex between peroxisome proliferator-activ...
ORGANISM(S): Homo sapiens 
2011-05-25 | E-GEOD-29489 | biostudies-arrayexpress
TranscriptomicsGenetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
Human induced pluripotent stem cells (hiPSCs) have potential for personalized and regenerative medicine. While most methods of utilizing these cells have focused on deriving homogenous populations of specialized cells, there has been modest success in producing hiPSC-derived organotypic tissues or o...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-74662 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of human cardiac progenitors and cardiomyocytes generated from embryonic bodies, directed differentiation of hESCs with PDGFa or co-culturing hESCs with END2 cell line.
Human cardiomyocytes can be generated from human embryonic stem cells (hESCs) in vitro by a variety of methods, including co-culture with visceral endoderm-like cell lines and growth factor directed differentiation as monolayers or three-dimensional embryonic bodies. To enable the identification, pu...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-MEXP-3371 | biostudies-arrayexpress
TranscriptomicsGene expression in the adrenal glands of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
We examined gene expression profiles in the rat adrenal glands using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis...
ORGANISM(S): Rattus norvegicus 
2013-04-16 | E-GEOD-31457 | biostudies-arrayexpress
TranscriptomicsHematopoietic progenitors from differentiating RUNX1cGFP human embryonic stem cells
In order to identify cells expressing RUNX1c during hematopoietic differentiation of human embryonic stem cells (hESCs), we targeted GFP downstream of the RUNX1 distal promoter. GFP was observed from 10-25 days of embryoid body differentiation and accurately mirrored expression of the endogenous RUN...
ORGANISM(S): Homo sapiens 
2012-02-12 | E-MEXP-3356 | biostudies-arrayexpress
TranscriptomicsLSEC: a microenvironment dependent differentiation program in rat including the novel junctional protein Leda-1
Liver sinusoidal endothelium (LSEC) is a prime example for organ-specific microvascular differentiation and functions. Disease-associated capillarization of LSEC in vivo and dedifferentiation of LSEC in vitro indicate the importance of the hepatic microenvironment. To identify the LSEC-specific mole...
ORGANISM(S): Rattus norvegicus 
2010-05-05 | E-GEOD-20375 | biostudies-arrayexpress
TranscriptomicsThe TIMP3/Apelin axis Regulates Atherosclerosis and Heart Metabolism leading to increased mortality in ApoE null Mice
The role of TIMP3 in the context of cardiovascular remodeling is relatively unexplored when considering classical risk factors such as hypercholesterolemia, diabetes and hypertension. To learn more the role of TIMP3 in the progression of cardiovascular disease we combined genetics, metabolomics and ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-53548 | biostudies-arrayexpress
TranscriptomicsCCAAT/Enhancer Binding Proteins (C/EBP)-M-NM-1 and -M-NM-2 are Essential for Ovulation, Luteinization and the Expression of Key Target Genes
Luteinizing hormone (LH) activation of the EGF receptor/RAS/ERK1/2 pathway is essential for ovulation and luteinization because granulosa cell depletion of Erk1/2 (Erk1/2gc-/- mice) renders mice completely infertile. Because of their potential as mediators of ERK1/2-dependent granulosa cell differe...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-23084 | biostudies-arrayexpress
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