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ProteomicsStudy of APOL1-containing complexes in podocytes
The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but also increase the risk of developing kidney disease. APOL1 and APOL3 are death-promoting proteins associated with endoplasmic reticulum and Golgi memb...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016851 | Pride
Podocytes Apol1 Kidney disease 
TranscriptomicsAPOL1 renal-risk variants induce mitochondrial dysfunction (Affymetrix 2)
To assess differential gene expression by APOL1 renal-risk (2 risk alleles) vs. non-risk (G0G0) genotypes in primary proximal tubule cells (PTCs), global gene expression (mRNA) levels were examined on Affymetrix HTA 2.0 arrays in primary PTCs cultured from non-diseased kidney in African Americans wi...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-85920 | biostudies-arrayexpress
TranscriptomicsIntegrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series. This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-68127 | biostudies-arrayexpress
GenomicsEvaluation of APOL1 ASO in a novel model of APOL1-associated renal disease
Evaluation of APOL1 ASO in a novel model of APOL1-associated renal disease
PRJNA496524 | ENA
TranscriptomicsAPOL1 renal-risk variants induce mitochondrial dysfunction (Illumina)
To elucidate pathways whereby apolipoprotein L1 gene (APOL1) G1 and G2 variants facilitate kidney disease in African Americans, human embryonic kidney cells (HEK293) were used to establish doxycycline-inducible (Tet-on) cell lines stably expressing reference APOL1 G0 and its G1 and G2 renal-risk var...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-85918 | biostudies-arrayexpress
GenomicsAPOL1 renal-risk variants induce mitochondrial fission
APOL1 renal-risk variants induce mitochondrial fission
PRJNA490827 | ENA
TranscriptomicsEvaluation of APOL1 ASO in a novel model of APOL1-associated renal disease
African Americans develop end-stage renal disease at a higher rate compared to European Americans due to two polymorphisms (G1 and G2 risk variants) in the apolipoprotein L1 (APOL1) gene that are common in people of African ancestry. Not all homozygous risk allele carriers, however, develop renal di...
ORGANISM(S): Mus musculus 
2018-10-16 | GSE121286 | GEO
GenomicsTranscriptomic analysis of ApoE-KO/APOL1 mouse choroid plexus
Transcriptomic analysis of ApoE-KO/APOL1 mouse choroid plexus
PRJNA1061484 | ENA
GenomicsTranscriptomic analysis of isolated zebrafish podocytes and endothelial cells exposed to human APOL1 mRNA
Transcriptomic analysis of isolated zebrafish podocytes and endothelial cells exposed to human APOL1 mRNA
PRJNA483985 | ENA
GenomicsCell-specific Inducible Human APOL1 Risk Variant Expression Cause Hypertension and Renal Damage
Cell-specific Inducible Human APOL1 Risk Variant Expression Cause Hypertension and Renal Damage
PRJNA1192267 | ENA
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