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TranscriptomicsTranscription profiling by array of mouse dendritic cells which were pulsed with apoptotic bodies from NIT-1 cells
We have been interested whether peripheral tolerance can be restored by vaccination with antigen-presenting cells (APCs) loaded with apoptotic bodies. Dendritic cells (DCs) are powerful APCs that have a critical role in the initiation and progression of autoimmunity. We previously demonstrated that ...
ORGANISM(S): Mus musculus 
2013-05-22 | E-MEXP-3374 | biostudies-arrayexpress
ProteomicsPANNEXIN-1 CHANNEL REGULATES NUCLEAR CONTENT PACKAGING INTO APOPTOTIC BODIES AND THEIR SIZE
Apoptotic bodies (ApoBDs), which are large extracullular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability. However, current limited understanding of ApoBD biology has hindered its exploration for cl...
ORGANISM(S): Homo sapiens (Human) 
2021-04-08 | PXD023988 | Pride
Pannexin 1 Apoptotic bodies Extracellular vesicles Nuclear proteins Dna Cargo sorting 
ProteomicsMolecular Profiling of Osteoclast Derived Apoptotic Bodies Reveals Extended Intercellular Regulations after Cell Death
Increasing evidences are revealing the important biological functions of apoptotic bodies (ABs). Here we identified the proteomic profiles of ABs from osteoclasts of distinct differentiation stages and investigated the potential functions. ABs were isolated from apoptotic bone marrow macrophages (BM...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD017245 | Pride
Molecular profiling of osteoclast derived apoptotic bodies reveals extended intercellular regulations after cell death 
TranscriptomicsApoptotic bodies unleash functional CXCL12 expression through microRNA-126
Apoptosis plays a pivotal role in embryogenesis and postnatal cell homeostasis, involving DNA or subcellular fragmentation, and shedding of small membranous microvesicles termed apoptotic bodies (AB). Following DNA damage, hypoxia, or vascular injury, the chemokine CXCL12 has been implicated in the ...
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-12696 | biostudies-arrayexpress
ProteomicsEfferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation
SARS-CoV-2 typically utilises host receptor angiotensin-converting enzyme 2 (ACE2) for viral entry. Despite low ACE2 expression, monocyte-derived macrophages, the predominant lung macrophage during severe COVID-19, are often found with SARS-CoV-2 in infected lungs. As macrophage inflammation and cyt...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD077914 | Pride
Covid-19 Apoptotic bodies Macrophage Inflammation Sars-cov-2 Apoptosis Infection Efferocytosis 
GenomicsBalance macrophage polarization via cell synthesis of apoptotic bodies in hydrogel microspheres
Balance macrophage polarization via cell synthesis of apoptotic bodies in hydrogel microspheres
PRJNA996561 | ENA
TranscriptomicsNovel critical insights into the mechanism of cell-based therapy after myocardial infarction
Cell transplantation therapy is considered a novel and promising strategy in regenerative medicine. Recent studies point out that paracrine effects and inflammation induced by transplanted cells are key factors for the improvement of myocardial function. The present study aims at differentiating par...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-48218 | biostudies-arrayexpress
GenomicsProfiling of mRNA, lncRNA and circRNA in Apoptotic Bodies during Osteoclastogenesis by RNA-seq
Profiling of mRNA, lncRNA and circRNA in Apoptotic Bodies during Osteoclastogenesis by RNA-seq
PRJNA546562 | ENA
ProteomicsEndothelial cell-derived apoptotic bodies modulate innate and adaptive immune responses during inflammation
Endothelial cells (ECs) act as gatekeepers and signalling hubs that coordinate communication between blood vessels and surrounding tissues by regulating vascular tone, immune responses and numerous other physiological processes. During vascular inflammation commonly associated with aging, atheroscle...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067178 | Pride
Human Lc-msms Endothelial Inflammation apoptosis 
GenomicsDifferential expression of keratinocyte-derived extracellular vesicle miRNAs discriminate exosomes from apoptotic bodies and microvesicles
Differential expression of keratinocyte-derived extracellular vesicle miRNAs discriminate exosomes from apoptotic bodies and microvesicles
PRJNA416912 | ENA
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