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UnknownProteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
Not available
S-EPMC3199338 | biostudies-literature
UnknownProteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease.
Not available
S-EPMC3517055 | biostudies-literature
TranscriptomicsDNA methylation profiles across different brain regions in APP/PSEN1 mice
Genome wide DNA methylation profiling of normal and APP/PSEN1 mice. A custom Illumina Golden Gate DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 800 CpGs. Bisulphite converted DNA from the 96 samples were hybridised to the Illumina custom golden gate DNA m...
ORGANISM(S): Mus musculus 
2015-12-05 | E-GEOD-42745 | biostudies-arrayexpress
TranscriptomicsEffect of ibuprofen on hippocampal gene expression in APP-PS1 mice
NSAIDs (non-steroidal anti-inflammatory drugs) inhibit cyclooxygenase (COX) enzymes and prevent Alzheimer'™s disease (AD) at preclinical stages in cognitively normal aging populations. We modeled NSAID prevention of memory impairment in AD model mice to identify novel targets of NSAID action. We fou...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-67306 | biostudies-arrayexpress
ProteomicsEvaluating cPILOT Performance on Orbitrap Instruments
A global cPILOT assay developed on an Orbitrap Velos instrument was transitioned to an Orbitrap Fusion Lumos instrument. Parameters such as the LC gradient, m/z isolation window, dynamic exclusion, targeted mass analyses, and SPS-N were optimized. The number of proteins identified on the Fusion Lumo...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD012133 | Pride
Proteomics Fusion lumos Alzheimer's disease Multiplexing Cpilot 
UnknownPresenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.
Not available
S-EPMC3766177 | biostudies-literature
Unknownγ-Secretase Inhibitors Selected by Molecular Docking, to Develop a New Drug Against Alzheimer's Disease.
Not available
S-EPMC10838598 | biostudies-literature
UnknownNanoplastics trigger glial-neuronal collagen signaling miscommunication to exacerbate cognitive impairment in Alzheimer's disease.
Not available
S-EPMC12823787 | biostudies-literature
UnknownHippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.
Not available
S-EPMC1615337 | biostudies-literature
TranscriptomicsSingle cell sequencing of astrocytes in the APP NL-F and APP PS1 models of ß-amyloidopathy
Bulk RNA-sequencing of astrocytes in the APP NL-F and APP PS1 models of ß-amyloidopathy, in which aspects of AD-related pathology progress at different speed, shows age-dependent gene expression changes. However, bulk RNA-seq does not provide insight into the heterogeneity of expression within this ...
ORGANISM(S): Mus musculus 
2024-03-21 | E-MTAB-13937 | biostudies-arrayexpress
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