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TranscriptomicsGenome-wide analysis of PIAS1 on AR gene expression in MDA-MB453
The majority of breast cancer subtypes express androgen receptor (AR) in addition to estrogen receptor α (ERα). Depending on the breast cancer subtype androgen signaling has either stimulatory or inhibitory roles in breast cancer cell growth. We have mapped AR cistrome in ERα negative human molec...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-70162 | biostudies-arrayexpress
GenomicsERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [AR ChIP]
ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [AR ChIP]
PRJNA661230 | ENA
ProteomicsGNL3 orchestrates AR transcriptional programs to drive castration-resistant prostate cancer and immune evasion
Androgen receptor (AR) signaling is a primary oncogenic driver of castration-resistant prostate cancer (CRPC), yet the mechanism remains incompletely understood. Dysregulation of the AR co-regulatory network has emerged as a key driver of castration resistance. To identify AR-interacting proteins li...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD067138 | Pride
Castration-resistant prostate cancer Ar coregulator Immunosuppression Gnl3 
GenomicsERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [AR ChIP]
We report the effects of ERG on prostate tumorigenesis, ERG-mediated oncogene addiction, and downstream AR signaling pathways. We determined that ERG facilitates AR-signaling and mediates transformation of prostate cells by maintaining coregulator complex formation at AR-bound sites across the genom...
ORGANISM(S): Mus musculus 
2020-09-04 | GSE157405 | GEO
ProteomicsAndrogen receptor RIME in prostate cancer cells
Androgen receptor (AR) is a master transcription factor that drives prostate cancer (PCa) development and progression. Alterations in the expression or activity of AR coregulators significantly impact the disease's outcome. To identify all the essential components of the AR coregulator complex, we u...
ORGANISM(S): Homo sapiens (Human) 
2022-07-12 | PXD031273 | Pride
Androgen receptor Prostate cancer Rime Cofactors 
OtherThe impact of WDR77 on the AR cistrome in prostate cancer cells
Androgen receptor (AR) drives prostate cancer (CaP) even after androgen deprivation therapy (ADT) failed. Inhibiting AR’s transcription factor function to overcome acquired resistance to ADT is an attractive therapeutic avenue. However, which AR-coregulator interaction should be targeted is not clea...
ORGANISM(S): Homo sapiens 
2025-01-10 | GSE252993 | GEO
UnknownNovel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer.
Not available
S-EPMC5497757 | biostudies-literature
GenomicsERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [ATAC]
We report the effects of ERG on prostate tumorigenesis, ERG-mediated oncogene addiction, and downstream AR signaling pathways. We determined that ERG facilitates AR-signaling and mediates transformation of prostate cells by maintaining coregulator complex formation at AR-bound sites across the genom...
ORGANISM(S): Mus musculus 
2020-09-04 | GSE157408 | GEO
GenomicsERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [ATAC]
ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [ATAC]
PRJNA661233 | ENA
GenomicsThe impact of WDR77 on the AR cistrome in prostate cancer cells
The impact of WDR77 on the AR cistrome in prostate cancer cells
PRJNA1063602 | ENA
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