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MetabolomicsSafety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
2026-04-29 | MTBLS14408 | MetaboLights
ProteomicsDetection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo
The immediate early gene product activity-regulated cytoskeleton-associate protein (Arc or Arg3.1) is a major regulator long-term synaptic plasticity with critical roles in postnatal cortical development and memory formation. However, the molecular basis of Arc function is not defined. Arc is a hub ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD039612 | Pride
Arc oligomer Dimer Rat brain 
ProteomicsEndogenous brain ARC complexes
Arc is an activity regulated neuronal protein yet little is known about its protein interactions, assembly into multiprotein complexes, role in human disease and cognition. We applied an integrated proteomic and genetic strategy using targeted tagging of a Tandem Affinity Purification (TAP) tag and ...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-19 | PXD007283 | Pride
Complexes Brain Mouse Lc-ms/ms 
GenomicsRapid transcription of arc/arg3.1 and other very fast immediate early genes in response to neuronal activity is mediated by a stalled RNA polymerase II mechanism
Transcription of immediate early genes (IEGs) in neurons is exquisitely sensitive to neuronal activity, but the mechanism underlying the earliest of these transcription events is largely unknown. Here we demonstrate that very fast IEGs (VF-IEGs) such as arc/arg3.1 are poised for rapid transcription ...
ORGANISM(S): Rattus norvegicus 
2011-05-24 | E-GEOD-22878 | biostudies-arrayexpress
TranscriptomicsNeurotoxin tetrodotoxin TTX withdrawal induced neuronal activity: RNA Pol II is poised for rapid induction of arc and other neuronal VF-IEGs
Transcription of immediate early genes (IEGs) in neurons is exquisitely sensitive to neuronal activity, but the mechanism underlying the earliest of these transcription events is largely unknown. Here we demonstrate that very fast IEGs (VF-IEGs) such as arc/arg3.1 are poised for rapid transcription ...
ORGANISM(S): Rattus norvegicus 
2011-04-14 | E-GEOD-22622 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 cells treated with ARC (NSC 188491)
ARC (NSC 188491, SMA-491), 4-amino-6-hydrazino-7-beta-d-ribofuranosyl-7H-pyrrolo-(2,3-d)-pyrimidine-5-carboxamide, is a nucleoside analog with profound in vitro anti-cancer activity. First identified in a high-throughput screen for inhibitors of p21 mRNA expression, subsequent experiments showed tha...
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13477 | biostudies-arrayexpress
TranscriptomicsArc/Arg3.1 functionally defines migrating 1 dendritic cells and regulates actin dynamics
We compared the expression profiles of bone marrow-derived dendritic cells (BMDC) derived from Arc/Arg3.1 knockout and wildtype animals. We generated bone marrow-derived dendritic cells (BMDC) from Arc/Arg3.1 knockout and wildtype animals. BMDC were either stimulated with LPS or left untreated and a...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-71937 | biostudies-arrayexpress
ProteomicsARC-SSMS-green-tea-metabolomics
green tea extracts analyzed with DDA MS for self service metabolomics training in the ARC MS facility at CSU
ORGANISM(S): Camellia Sinensis (ncbitaxon:4442) 
2023-02-09 | MSV000091238 | MassIVE
GenomicsEnvironment Arc
Environment Arc Raw sequence reads
PRJNA1195386 | ENA
GenomicsEnviroment Arc
Enviroment Arc Raw sequence reads
PRJNA1303322 | ENA
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