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GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
ProteomicsArginine dimethylation and liquid-liquid phase separation
Recently, arginine methylation was found to regulate the protein LLPS which drives the formation of MLOs. Here, we developed a chemical enrichment method coupled with LC-MS/MS to analyze dynamic change of arginine di-methylation upon SG formation.
ORGANISM(S): Homo sapiens (Human) 
2022-10-20 | PXD033048 | Pride
Liquid-liquid phase separation Arginine dimethylation Chemical enrichment method Stress granule Rg/rgg motifs 
ProteomicsArginine dimethylation and liquid-liquid phase separation_Supplementary
Recently, arginine methylation was found to regulate the protein LLPS which drives the formation of MLOs. Here, we developed a chemical enrichment method coupled with LC-MS/MS to analyze dynamic change of arginine di-methylation upon SG formation.
ORGANISM(S): Homo sapiens (Human) 
2022-10-20 | PXD035137 | Pride
Liquid-liquid phase separation Arginine dimethylation Chemical enrichment method Stress granule Rg/rgg motifs 
ProteomicsComprehensive analysis of symmetric arginine dimethylation in colorectal cancer tissues from patients using immuniaffinity enrichment followed by LC-MS/MS analysis
Post-translational arginine methylation is responsible for regulation of a variety of biological processes. The protein arginine methyltransferase 5 (PRMT5) is the major enzyme responsible for generating monomethyl- and symmetric dimethyl arginine (MMA and SDMA, respectively) in proteins. PRMT5 is e...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD015653 | Pride
Prmt5 Immunoaffinity enrichment Colorectal cancer Mass spectrometry Symmetric arginine methylation 
TranscriptomicsDistinct transcriptional outputs associated with mono- and di-methylated histone H3 arginine 2
Dimethylation of histone H3 arginine 2 (H3R2me2) maintains transcriptional silencing by inhibiting Set-1 mediated trimethylation of H3K4. Here we demonstrate that arginine 2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (a) H3R2me1 does ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-06 | E-GEOD-14453 | biostudies-arrayexpress
UnknownStructural insights into protein arginine symmetric dimethylation by PRMT5.
Not available
S-EPMC3251124 | biostudies-literature
UnknownOpto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition.
Not available
S-EPMC11873949 | biostudies-literature
TranscriptomicsProtein arginine methyltransferase AtPRMT5 is involved in pre-mRNA splicing in Arabidopsis thaliana
In this study, we analyzed the Arabidopsis homologue of PRMT5, AtPRMT5M-bM-^@M-^Ys function in RNA processing. RNA-seq analyses revealed that AtPRMT5 is involved in a subset of pre-mRNA splicing. Several RNA processing factors involved in regulating flowering time were validated that the correspondi...
ORGANISM(S): Arabidopsis thaliana 
2010-10-07 | E-GEOD-21323 | biostudies-arrayexpress
ProteomicsRepression of PRMT5-mediated dimethylation stabilizes vimentin and promotes metastasis in MTAP-loss lung cancer
Abstract The aggressive nature and poor prognosis of lung cancer led us to explore the mechanisms driving disease progression. Utilizing our invasive cell-based model, we identified methylthioadenosine phosphorylase (MTAP) and confirmed its suppressive effects on tumorigenesis and metastasis, and pa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031192 | Pride
Human Dimethylation Lung cancer 
UnknownOrganellar proteomics reveals Golgi arginine dimethylation.
Not available
S-EPMC420113 | biostudies-literature
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