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ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021636 | Pride
Tmt Mesc Arid1a depletion 
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021631 | Pride
Arid1a depeltion Ip-ms Mesc 
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021624 | Pride
Ip-ms Mesc Arid1a depletion 
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021623 | Pride
Arid1a Tmt Ip-ms Mesc 
TranscriptomicsGene expression data ARID1A knockdown OE33 cells versus mock OE33 cells
A nonsense mutation in ARID1A was identified by next generation sequencing in non-dysplastic Barrett's esophagus [BE] tissue and esophageal adenocarcinoma [EAC] tissue of a patient diagnosed with EAC. Immunohistochemistry performed on an independent archival cohort demonstrated ARID1A protein loss i...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-38380 | biostudies-arrayexpress
TranscriptomicsmRNA-seq for HCT116 Parental and ARID1A knockdown cells, mRNA-seq for DLD1 Parental, ARID1A knockdown and ARID1A knockout cells, mRNA-seq for COLO320DM Parental and ARID1A knockdown and ARID1A knockout cells
The study identifies genes that are regulated by the loss of the chromatin remodeller subunit ARID1A in colorectal cancer cell lines. This gene is frequently mutated in colorectal cancer.
ORGANISM(S): Homo sapiens 
2019-06-11 | E-MTAB-7791 | biostudies-arrayexpress
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021824 | Pride
Arid1a depeltion Ip-ms Mesc Swi/snf 
ProteomicsBRD3 mediates transcriptional reprogramming in ARID1A-deficient ER+ breast cancer
Metastasis is the major cause of breast cancer-related deaths. ARID1A mutations occur in up to 12% of ER+ breast cancer metastasis, resulting in resistance to endocrine therapy, but an unexpected gain in sensitivity to BET inhibitors. Using the mouse intraductal xenografting model we showed that the...
ORGANISM(S): Homo sapiens (Human) 
2026-10-08 | PXD051554 | Pride
Tumour metastasis Arid1a loss Bet inhibitors 
ProteomicsARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. However, it is challenging to predict how ARID1A loss might impact on responses to cancer therapies because it participates in many different cellular pathways. G quadruplex (G4) binding ligands, such ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-15 | PXD063556 | Pride
G4 ligands Arid1a 
ProteomicsARID1A regulates transcription and the epigenetic landscape via POLE and DMAP1 while ARID1A deficiency or pharmacological inhibition sensitizes germ cell tumor cells to ATR inhibition
Germ cell tumors (GCTs) are the most common solid malignancies in young men. Although high cure rates can be achieved at early stages, metastases, resistance to cisplatin-based therapy, and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In a previou...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD017898 | Pride
Molecular therapy Swi/snf-complex Mass spectrometry Hdac inhibitors Crispr/cas9 Atr inhibitors Arid1a Germ cell tumors 
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