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ProteomicsReconstitution of mammalian Cleavage Factor II
Cleavage factor II (CF II) is a poorly characterized component of the multi-protein complex catalyzing 3' cleavage and polyadenylation of mammalian mRNA precursors. We have reconstituted CF II as a heterodimer of hPcf11 and hClp1. The heterodimer is active in partially reconstituted cleavage reactio...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010177 | Pride
Human Rna processing Dsbu 
ProteomicsRevisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels
The NAD⁺-dependent deacetylase sirtuin 1 (Sirt1) is known to regulate the tumor suppressor p53 via deacetylation, but the structural basis of the protein-protein interaction between full-length Sirt1 and p53 has so far remained elusive. We apply an integrated approach, combining structural mass spe...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072665 | Pride
Sirtuin 1 Cross-linking Mass spectrometry P53 
ModelsMammalian Cell Cycle
BACKGROUND: In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2 is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic intervention, ERBB2 is targeted by monoclonal antibody trastuzumab in adjuvant settings; however, de novo resistance to t...
1607 | Cell Collective
ProteomicsMS analysis of SARS-CoV2 proteins from patient samples
We developed a simple, MS-based method to specifically detect SARS-CoV-2 proteins from gargle solution samples of COVID-19 patients. Our protocol consists of an acetone precipitation and tryptic digestion of proteins contained within the gargle solution, followed by a targeted MS analysis. Our metho...
ORGANISM(S): Homo sapiens (Human) 
2020-06-26 | PXD019423 | Pride
Covid-19 Nucleoprotein Sars-cov-2 Mass spectrometry 
ProteomicsMS analysis of SARS-CoV2 proteins from patient samples
We developed a simple, MS-based method to specifically detect SARS-CoV-2 proteins from gargle solution samples of COVID-19 patients. Our protocol consists of an acetone precipitation and tryptic digestion of proteins contained within the gargle solution, followed by a targeted MS analysis. Our metho...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-16 | MSV000085761 | MassIVE
UnknownHepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.
Not available
S-EPMC3478098 | biostudies-literature
UnknownLung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
Not available
S-EPMC8760276 | biostudies-literature
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