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TranscriptomicsExpression data from a human MLL-AF6 positive AML cell line
The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation ...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-43068 | biostudies-arrayexpress
UnknownActivity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection.
Not available
S-EPMC5959882 | biostudies-literature
TranscriptomicsGene expression data from children diagnosed with ALL in vitro sensitive or resistant to prednisolone
Although the prognosis for childhood Acute Lymphoblastic Leukemia (ALL) in general has improved tremendously over the last decades, the survival chances for infants (<1 year of age) with ALL remains poor. A major obstacle hampering successful treatment results in infant ALL is cellular resistance to...
ORGANISM(S): Homo sapiens 
2009-12-15 | E-GEOD-19143 | biostudies-arrayexpress
GenomicsEpigenetic profiling of hematopoietic stem cells and leukemia stem cells
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations that involve the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in a murine MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K7...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-29130 | biostudies-arrayexpress
UnknownLinking the Cherokee Nation Cancer Registry With Electronic Medical Records: A Tribal-Academic Center Partnership.
Not available
S-EPMC9142483 | biostudies-literature
TranscriptomicsExpression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML
We evaluated gene expression changes in secondary recipient murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of a homozygous conditional allele for Ezh2, a component of the Polycomb Re...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34961 | biostudies-arrayexpress
ProteomicsComparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites
Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of approximately 6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No vaccine exists for the major filaria...
ORGANISM(S): Litomosoides sigmodontis (Filarial nematode worm) 
2014-07-22 | PXD000756 | Pride
Filarial nematode Excretory-secretory products Lc-ms/ms Litomosoides sigmodontis 
GenomicsGenome-wide map of JMJD1C binding in Kasumi-1 cells [ChIP-seq]
The AML1-ETO fusion protein, a transcription factor generated by the t(8;21) translocation in acute myeloid leukaemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a co-activator for...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-63484 | biostudies-arrayexpress
TranscriptomicsExpression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML
We evaluated gene expression changes in murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of homozygous conditional alleles for Ezh2 or Eed, both of which are components of the Polycomb...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34959 | biostudies-arrayexpress
UnknownStructure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus.
Not available
S-EPMC3985756 | biostudies-literature
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