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ProteomicsEffects of accute depletion of Lamins on nuclear envelope-associated proteins
The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. Here, we apply the auxin-inducible degron (AID) system to rapidly deplete each lamin isoform within ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD061149 | Pride
Lamin a/c Lamin b1 Lamin b2 Npc 
ProteomicsDistinct Basket Nucleoporins roles in Nuclear Pore Function and Gene Expression
Nuclear pore complexes (NPCs) are important for cellular functions beyond nucleocytoplasmic trafficking, including genome organization and gene expression. This multi-faceted nature and the slow turnover of NPC components complicates investigations of how individual nucleoporins act in these diverse...
ORGANISM(S): Homo sapiens (Human) 
2020-06-30 | PXD020075 | Pride
Auxin-inducible degron Human Nuclear pore complex 
ProteomicsTotal proteome analysis of DLD-1 cells expressing various degrons
Total Proteome analysis of various AID degron-bearing DLD-1 cells ( Nup96, Nup62, Nup188, TPR, Nup93, GANP, PCID2, Nup153, Nup160, Nup205) before and after addition of Auxin for 4-8 h.
ORGANISM(S): Homo sapiens (Human) 
2023-03-31 | PXD039407 | Pride
Total lysate Human dld-1 cells 
UnknownThe SUMO protease SENP6 is essential for inner kinetochore assembly
Not available
S-JCBD-200909008 | bioimages
ProteomicsiTRAQ quantification of ectopic expression of mei-cohesin complexes in DLD1 cells
iTRAQ quantification project, for 6 Homo_sapiens samples named DLD1-1, DLD1-2, DLD1-STAG3-SMC1B-REC8-1, DLD1-STAG3-SMC1B-REC8-2, DLD1-STAG3-SMC1B-RAD21L-1, DLD1-STAG3-SMC1B-RAD21L-2
ORGANISM(S): Homo Sapiens 
2021-03-12 | PXD024713 |
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