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ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD045812 | Pride
Viral replication Live-cell imaging Sars-cov-2 Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD045783 | Pride
Viral replication Live-cell imaging Sars-cov-2 Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-04-30 | PXD045916 | Pride
Viral replication Live-cell imaging Sars-cov-2 Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD045929 | Pride
Viral replication Live-cell imaging Sars-cov-2 Rtcb Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
GenomicsA single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation progrmme (bulk RNA-seq of arrayed CRISPRa validations and bulk RNA-seq of Patz1, Dppa2, Smarca5 and Carhsp1 cDNA overexpression)
A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation progrmme (bulk RNA-seq of arrayed CRISPRa validations and bulk RNA-seq of Patz1, Dppa2, Smarca5 and Carhsp1 cDNA overexpression)
PRJNA559151 | ENA
TranscriptomicsA single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation progrmme (bulk RNA-seq of arrayed CRISPRa validations and bulk RNA-seq of Patz1, Dppa2, Smarca5 and Carhsp1 cDNA overexpression)
Zygotic genome activation (ZGA) is a crucial developmental milestone that remains poorly understood. This first essential transcriptional event in embryonic development coincides with extensive epigenetic reprogramming and is orchestrated, in part, by the interplay of transcriptional and epigenetic ...
ORGANISM(S): Mus musculus 
2020-07-05 | GSE135512 | GEO
TranscriptomicsA single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation programm (10X Genomics CRISPRa screen dataset)
Zygotic genome activation (ZGA) is a crucial developmental milestone that remains poorly understood. This first essential transcriptional event in embryonic development coincides with extensive epigenetic reprogramming and is orchestrated, in part, by the interplay of transcriptional and epigenetic ...
ORGANISM(S): Mus musculus 
2020-07-05 | GSE135621 | GEO
GenomicsA single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation programm (10X Genomics CRISPRa screen dataset)
A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation programm (10X Genomics CRISPRa screen dataset)
PRJNA559476 | ENA
TranscriptomicsA single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation programme (bulk RNA-seq of E14 and SAM mESCs dataset)
Zygotic genome activation (ZGA) is a crucial developmental milestone that remains poorly understood. This first essential transcriptional event in embryonic development coincides with extensive epigenetic reprogramming and is orchestrated, in part, by the interplay of transcriptional and epigenetic ...
ORGANISM(S): Mus musculus 
2020-07-05 | GSE135509 | GEO
TranscriptomicsA single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of the zygotic genome activation programme (10X Genomics 3' scRNA-seq of MERVL LTR and Zscan4 CRISPRa dataset)
Zygotic genome activation (ZGA) is a crucial developmental milestone that remains poorly understood. This first essential transcriptional event in embryonic development coincides with extensive epigenetic reprogramming and is orchestrated, in part, by the interplay of transcriptional and epigenetic ...
ORGANISM(S): Mus musculus 
2020-07-05 | GSE135554 | GEO
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