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ProteomicsA Conformationally Arrested Peptidomimetic Antibiotic Disrupts Selectively the Outer Membrane in Escherichia coli
Using a shotgun proteomics approach, the expressed proteome of total membrane fractions of Escherichia coli ATCC25922 cells was analyzed under i) normal growth, and ii) treatment with the novel peptidomimetic JB-95 (a structurally arrested cyclic peptide). By selectively disrupturing the outer membr...
ORGANISM(S): Escherichia coli 
2015-12-07 | PXD002588 | Pride
Shotgun proteomics Novel antibiotic Arrested cyclic peptide Om rupture New moa E. coli Total membrane fraction 
UnknownDerivates of the Antifungal Peptide Cm-p5 Inhibit Development of Candida auris Biofilms In Vitro.
Not available
S-EPMC7400495 | biostudies-literature
TranscriptomicsTranscription profiling of human monocytic cells THP-1 stimulated with LPS (10ng/ml) in presence or absence of LL-37 (5 ug/ml), as well as with the peptide alone, for 4 hours
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence or absence of host defense peptide LL-37 at low physiologically relevant concentrations. Human monocytic cells THP-1 were stimulated with LPS (10ng/ml) in presence or absenc...
ORGANISM(S): Homo sapiens 
2006-12-07 | E-FPMI-6 | biostudies-arrayexpress
UnknownCyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.
Not available
S-EPMC449752 | biostudies-literature
TranscriptomicsRNAseq of S. stercoralis PV001 strain L3i activation
RNAseq study to examine regulation of S. stercoralis transcripts during L3i activation
ORGANISM(S): Strongyloides_stercoralis 
2014-07-01 | E-MTAB-2192 | biostudies-arrayexpress
UnknowncGMP and NHR signaling co-regulate expression of insulin-like peptides and developmental activation of infective larvae in Strongyloides stercoralis.
Not available
S-EPMC4092141 | biostudies-literature
UnknownRole of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.
Not available
S-EPMC9890476 | biostudies-literature
UnknownE2/ER signaling mediates the meiotic arrest of goat intrafollicular oocytes induced by follicle-stimulating hormone.
Not available
S-EPMC10630185 | biostudies-literature
TranscriptomicsTranscription profiling of preadipocytes of wild type and IRS-1,IRS-2, IRS-3, IRS-4 knock out mice to reveal role of insulin receptor substrates and necdin
Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to ...
ORGANISM(S): Mus musculus 
2007-08-04 | E-GEOD-2556 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human NIH-3T3 fibroblasts stably expressing the coxsackie-adenovirus receptor (CARI?1)) cells were transduced with adenovirus containing empty vector (AdEmpty) followed by addition of vehicle (DMSO) or transduced with adenovirus encoding either full length HA-tagged PPARg2 or A/B-domain deleted HA-PPARgCDE and treated with rosiglitazoneNIH-3T3 fibroblasts stably expressing the coxsackie-adenovirus receptor (CARI?1)) cells were transduced with adenovirus containing empty vector (AdEmpty) followed by addition of vehicle (DMSO) or transduced with adenovirus encoding either full length HA-tagged PPARg2 or A/B-domain deleted HA-PPARgCDE and treated with rosiglitazone reveals the PPARg2 A/B-domain plays a gene specific role in transactivation and co-factor recruitment
We have previously shown that adenoviral expression of peroxisome proliferator-activated receptors (PPARs) leads to rapid establishment of transcriptionally active complexes and activation of target gene expression within 5-8 h following transduction. Here we have used the adenoviral delivery system...
ORGANISM(S): Mus musculus 
2009-04-04 | E-GEOD-15433 | biostudies-arrayexpress
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