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TranscriptomicsMicroRNA profiling by array of miRNAs regulated by Ars2 and DGCR8
siRNAs were used to deplete either Ars2 or DGCR8 proteins from cells and were compared to control siRNA treated cells.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MTAB-898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mRNAs regulated by Ars2 and DGCR8
siRNAs were used to deplete either Ars2 or DGCR8 proteins from cells and were compared to control siRNA treated cells.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MTAB-899 | biostudies-arrayexpress
ProteomicsStructural analysis of human ARS2, a platform for co-transcriptional RNA sorting
ARS2 is a highly conserved metazoan protein involved in numerous aspects of nuclear RNA metabolism. As a direct partner of the nuclear cap-binding complex (CBC) it mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Here we present the human ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD009035 | Pride
Protein interaction Ars2 
TranscriptomicsEffects of Ars2 or DGCR8 siRNA on gene expression
Ars2 is a component of the nuclear cap-binding complex that is required for cellular proliferation and contributes to microRNA biogenesis. Arrays were performed to determine the repertoire of genes that change following knock-down of Ars2. Knock-down of DGCR8 was also performed to determine which c...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-34679 | biostudies-arrayexpress
TranscriptomicsEffects of Ars2 or DGCR8 siRNA on gene and microRNA expression
This SuperSeries is composed of the following subset Series: GSE34679: Effects of Ars2 or DGCR8 siRNA on gene expression GSE34680: Effects of Ars2 or DGCR8 siRNA on microRNA expression Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-34681 | biostudies-arrayexpress
TranscriptomicsEffects of Ars2 or DGCR8 siRNA on microRNA expression
Ars2 is a component of the nuclear cap-binding complex that is required for cellular proliferation and contributes to microRNA biogenesis. Arrays were performed to determine the repertoire of microRNAs that change following knock-down of Ars2. Knock-down of DGCR8 was also performed to determine whi...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-34680 | biostudies-arrayexpress
TranscriptomicsCBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing
The nuclear cap-binding complex (CBC) stimulates multiple steps in several RNA maturation pathways, but how it functions in humans is incompletely understood. For small capped RNAs like pre-snRNAs, the CBC recruits PHAX. Here, we identify the CBCAP complex, composed of CBC, Ars2 and PHAX, and show t...
ORGANISM(S): Homo sapiens 
2013-11-08 | E-GEOD-52131 | biostudies-arrayexpress
GenomicsRegulation of embryonic and adult neurogenesis by Ars2
Regulation of embryonic and adult neurogenesis by Ars2
PRJNA553785 | ENA
GenomicsZC3H4, ARS2, and WDR82 coordinate non-coding transcriptional termination and are opposed by telescripting on protein-coding genes [ars2-zc3h4_double_degron]
ZC3H4, ARS2, and WDR82 coordinate non-coding transcriptional termination and are opposed by telescripting on protein-coding genes [ars2-zc3h4_double_degron]
PRJNA855386 | ENA
UnknownRegulation of embryonic and adult neurogenesis by Ars2.
Not available
S-EPMC6983708 | biostudies-literature
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