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TranscriptomicsRNAi profiling by array of human U-2-OS osteosarcoma cells with knockdown of Asf1a and Asf1b
We used RNAi to knock-down the two isoforms of Asf1, Asf1a and Asf1b, in human U-2-OS osteosarcoma cells. We obtained two replicates each with siRNAs against Asf1a, Asf1b, combined siRNAs against both isoforms, and two control samples. For these samples, we measured genome-wide transcription levels ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-MEXP-2671 | biostudies-arrayexpress
GenomicsRNA-seq to compare gene expression profiles between Asf1a WT and Asf1a KO cells
RNA-seq to compare gene expression profiles between Asf1a WT and Asf1a KO cells
PRJNA524337 | ENA
ProteomicsTousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication
During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-Like Kinases (TLKs). Here, we identify TLK phosphorylation sites by mass spectrometry and ...
ORGANISM(S): Homo sapiens (Human) 
2014-03-06 | PXD000686 | Pride
Asf1b Thermolysin Asf1a Phosphopeptide 
GenomicsGenome-wide maps of chromatin state for HIRA, UBN1 and ASF1a
The HIRA chaperone complex, comprised of HIRA, UBN1 and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner. To better understand its function and mechanism, we integrated HIRA, UBN1, ASF1a and histone H3....
ORGANISM(S): Homo sapiens 
2013-04-18 | E-GEOD-45024 | biostudies-arrayexpress
TranscriptomicsASF1
Transcription profiling by array of HeLa cells after the knock-down of ASF1 (ASF1a & ASF1b) by siRNA compared to non-targeting control siRNA
ORGANISM(S): Homo sapiens 
2014-01-14 | E-MTAB-1909 | biostudies-arrayexpress
TranscriptomicsRNA-seq to compare gene expression profiles between Asf1a WT and Asf1a KO cells
KrasG12D/P53-/-(KP)-Cas9 single clone was transfected with ctrl vector, ctrl sgRNA-1, ctrl-sgRNA-2 or ctrl-sgRNA-3 and then selected by using 5ug/ml Blasticidin, to get the 4 ctrl lines; KP-Cas9 single clone was transfected with Asf1a sgRNA-1, sgRNA-2, sgRNA-3 and new sgRNA-1 and then selected by us...
ORGANISM(S): Mus musculus 
2019-11-26 | GSE127205 | GEO
GenomicsAsf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation
Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation
PRJNA471334 | ENA
GenomicsIn vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma
In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma
PRJNA576429 | ENA
UnknownASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells.
Not available
S-EPMC6349940 | biostudies-literature
GenomicsGenome-wide maps of chromatin state for HIRA, UBN1 and ASF1a
The HIRA chaperone complex, comprised of HIRA, UBN1 and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner. To better understand its function and mechanism, we integrated HIRA, UBN1, ASF1a and histone H3....
ORGANISM(S): Homo sapiens 
2013-04-18 | GSE45024 | GEO
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