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ProteomicsThe LHX2-OTX2 regulatory module controls RPE differentiation and underlies a causal regulatory risk-SNP in age-related macular degeneration
Tissue-specific transcription factors control the transcriptome through an association with noncoding regulatory regions (cistromes). Identifying the combination of transcription factors that dictate specific cell fate, their specific cistromes and examining their involvement in complex human traits...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038485 | Pride
Ldb1 Retinal pigmented epithelium : lhx2 Cell-differentiation Otx2 Amd Risk-snp 
GenomicsIdentification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during lens and forebrain development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation and cell fate specification...
ORGANISM(S): Mus musculus 
2015-07-09 | E-GEOD-66961 | biostudies-arrayexpress
TranscriptomicsPAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium through Feed-Forward Regulatory Interactions with MITF
During organogenesis, PAX6 is required for establishment of various progenitor subtypes within the central nervous system, eye and pancreas. PAX6 expression is maintained in a variety of cell types within each organ, although its role in each lineage and how it acquires cell-specific activity remain...
ORGANISM(S): Mus musculus 
2014-04-08 | E-GEOD-56548 | biostudies-arrayexpress
TranscriptomicsChromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and their denucleation [lens tissue]
Genome-wide approach to identify the cell-autonomous role of Brg1 in lens fiber cell terminal differentiation. To examine roles of Brg1 in mouse lens development, a dnBrg1 transgenic construct was expressed using the lens-specific alphaA-crystallin promoter in postmitotic lens fiber cells. Morpholog...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22322 | biostudies-arrayexpress
TranscriptomicsChromatin Remodeling Enzyme Smarca5/Snf2h Regulates Cell Cycle Exit, Differentiation of the Lens Epithelium, and Denucleation of Lens Fiber Cells
Genome-wide approach to identify the cell-autonomous role of Snf2h in lens fiber cell terminal differentiation. Differential gene expression was analyzed in Snf2h lens-conditional knockout and wildtype newborn mouse eyeballs, with subsequent comparison of this data with the Brg1 lens-conditional kno...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41608 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of FGF2-dependent mRNA:microRNA networks during lens fiber cell differentiation
Background: FGF signaling controls numerous processes during cell lineage specification, organogenesis and terminal differentiation. In lens, FGF signaling was implicated as the key pathway that controls lens fiber cell differentiation, but little is known about its full range and spectrum of regula...
ORGANISM(S): Rattus norvegicus 
2013-09-06 | E-GEOD-50604 | biostudies-arrayexpress
TranscriptomicsChromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and their denucleation [eyeball tissue]
Genome-wide approach to identify the cell-autonomous role of Brg1 in lens fiber cell terminal differentiation. Differential gene expression was analyzed in Brg1 lens-conditional knockout and wildtype newborn mouse eyeballs, with subsequent comparison of this data with the dnBrg1 mouse lenses expre...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-25168 | biostudies-arrayexpress
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