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ProteomicsTranscription factor-SNP interactome for colorectal cancer risk loci
A core task to understand the consequences of non-coding single nucleotide polymorphisms (SNP) is to identify their genotype specific binding of transcription factor (TF). Here, we generate a large-scale TF-SNP interaction map for a selection of 116 colorectal cancer (CRC) risk loci and validated TF...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080810 | MassIVE
ProteomicsTranscription factor-SNP interactome for colorectal cancer risk loci
A core task to understand the consequences of non-coding single nucleotide polymorphisms (SNP) is to identify their genotype specific binding of transcription factor (TF). Here, we generate a large-scale TF-SNP interaction map for a selection of 116 colorectal cancer (CRC) risk loci and validated TF...
ORGANISM(S): Homo sapiens (Human) 
2017-02-23 | PXD004435 | Pride
Human Transcription factor Cancer related snp Colorectal cancer 
ProteomicsThe LHX2-OTX2 regulatory module controls RPE differentiation and underlies a causal regulatory risk-SNP in age-related macular degeneration
Tissue-specific transcription factors control the transcriptome through an association with noncoding regulatory regions (cistromes). Identifying the combination of transcription factors that dictate specific cell fate, their specific cistromes and examining their involvement in complex human traits...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038485 | Pride
Ldb1 Retinal pigmented epithelium : lhx2 Cell-differentiation Otx2 Amd Risk-snp 
GenomicsRisk SNP-mediated enhancer-promoter interaction drives keloid through lncRNA DEIK
Risk SNP-mediated enhancer-promoter interaction drives keloid through lncRNA DEIK
PRJNA835406 | ENA
ProteomicsRisk SNP rs11067228-mediated high-order chromatin interactions drive prostate cancer neuroendocrine differentiation through splicing factor SRRM4
Neuroendocrine prostate cancer is an aggressive disease characterized by early metastasis, drug resistance and poor prognosis. Genome-wide association studies (GWAS) previously identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer. SNP rs11067228 as a significant...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD055628 | Pride
Snp rs11067228  enhancer  long-range chromatin interaction  neuroendocrine differentiation  prostate cancer 
TranscriptomicsAffymetrix SNP array data for NF1-associated glioma risk
We performed whole genome SNP profiling on DNA samples from 236 patients with NF1, 123 with glimoa tumors and 113 without; 117 females and 119 males, together with 29 control samples. To identify polymorphisms in human adenylate cyclase 8 (AC8) which correlate with glioma risk in NF1 in a sex-speci...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-62215 | biostudies-arrayexpress
GenomicsAffymetrix SNP array data for NF1-associated glioma risk
We performed whole genome SNP profiling on DNA samples from 236 patients with NF1, 123 with glimoa tumors and 113 without; 117 females and 119 males, together with 29 control samples. To identify polymorphisms in human adenylate cyclase 8 (AC8) which correlate with glioma risk in NF1 in a sex-specif...
ORGANISM(S): Homo sapiens 
2015-02-20 | GSE62215 | GEO
TranscriptomicsAffymetrix SNP 6.0 data for individuals with Trisomy 21 or Down syndrome
Individuals with Down syndrome (DS) are at an increased risk for developing congenital heart defects especially atrioventricular septal defects (AVSD). Our goal was to identify the contribution of copy number variants (CNV) to DS-associated AVSD. We used the Affymetrix SNP 6.0 genotyping platform to...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-60607 | biostudies-arrayexpress
GenomicsThe risk SNP rs11067228 promotes prostate cancer drug resistance and neuroendocrine differentiation through 3D chromatin interactions (4C-seq data set)
The risk SNP rs11067228 promotes prostate cancer drug resistance and neuroendocrine differentiation through 3D chromatin interactions (4C-seq data set)
PRJNA1145309 | ENA
GenomicsThe risk SNP rs11067228 promotes prostate cancer drug resistance and neuroendocrine differentiation through 3D chromatin interactions (RNA-seq data set)
The risk SNP rs11067228 promotes prostate cancer drug resistance and neuroendocrine differentiation through 3D chromatin interactions (RNA-seq data set)
PRJNA1145310 | ENA
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