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TranscriptomicsRNA-seq of human mesenchymal stem cells inducibly overexpressing human ataxin-1(Q82)
A protein aggregation model of human ataxin-1(Q82) was generated in human mesenchymal cells using the Sleeping Beauty transposon system. These cells inducibly express the pathogenic protein that causes SCA1 disease. Here, we describe the transcriptional changes occurring in cells which contain diffe...
ORGANISM(S): Homo sapiens 
2020-02-18 | E-MTAB-7713 | biostudies-arrayexpress
ProteomicsComplementary proteomics strategies identify the ataxin-1 interactome in Neuro-2a cells
To identify protein partners of ataxin-1 in neuronal cells under control or stress conditions, we use complementary proteomics strategies of proximity-dependent biotin identification (BioID) and affinity purification (via GFP-trap pulldown) in Neuro-2a cells expressing epitope-tagged forms of ataxin...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010352 | Pride
Gfp-trap Ataxin-1 Bioid Interactome Neuro-2a Lc – msms 
TranscriptomicsTranscription profiling of ataxin-null (Atxn-null) vs. wild type mice to investigate spinocerebellar ataxia type 1 (SCA1)
Ataxin 1 (Atxn1) is a protein of unknown function associated with cerebellar neurodegeneration in spinocerebellar ataxia type 1 (SCA1). SCA1 is caused by an expanded polyglutamine within Atxn1 by gain-of-function mechanisms. Lack of Atxn1 in mice triggers motor deficits in the absence of neurodegene...
ORGANISM(S): Mus musculus 
2006-12-01 | E-MEXP-886 | biostudies-arrayexpress
ProteomicsPolyQ-expanded ataxin-1 formed insoluble protein inclusions perturbing translation in a spinocerebellar ataxia type-1 model
Spinocerebellar ataxia type-1 is caused by an abnormally expanded polyglutamine (polyQ) tract in ataxin-1 protein. These expansions are responsible for protein misfolding and self-assembly into intranuclear inclusion bodies (IIBs) that are linked to neuronal death. Here, we describe a nuclear protei...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD012709 | Pride
Ataxin-1 Sleeping beauty transposon Protein network Polyglutamine Afm Ribosome Nucleolus. Spinocerebellar ataxia type-1 Rna-seq 
GenomicsRNA-seq of human mesenchymal stem cells inducibly overexpressing human ataxin-1(Q82)
RNA-seq of human mesenchymal stem cells inducibly overexpressing human ataxin-1(Q82)
PRJEB31344 | ENA
ProteomicsAtxn2-Knock-Out mice show branched chain amino acids and fatty acids pathway alterations
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1 and hypertension in genome-wide association studies, while mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance and dyslipidemia. Intriguingly, the deficiency of ATXN2...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084933 | MassIVE
TranscriptomicsHMGB1 contributes to mitochondrial DNA damage repair and extends lifespan in mutant ataxin-1 knock-in mice
Mutant ataxin-1 (Atxn1), which causes spinocerebellar ataxia type 1 (SCA1), binds to and impairs the function of high mobility group box 1 (HMGB1), a critical nuclear protein that regulates DNA architectural changes essential for DNA damage repair and transcription. In this study, we established tha...
ORGANISM(S): Mus musculus 
2015-01-05 | E-MTAB-2987 | biostudies-arrayexpress
UnknownFOX-2 dependent splicing of ataxin-2 transcript is affected by ataxin-1 overexpression.
Not available
S-EPMC3364202 | biostudies-literature
Genomics
HEK-293T cells expressing mutant ataxin-1
PRJNA688985 | ENA
UnknownBoat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.
Not available
S-EPMC1224676 | biostudies-literature
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