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TranscriptomicsATF4 governs functional expansion of hematopoietic stem cells partially via Angptl3 in the fetal liver microenvironment (array)
In this study, we demonstrated that deletion of the activating transcription factor 4 (ATF4) resulted in severely impaired HSC expansion in the fetal liver at E12.5 and E15.5. In contrast, generation of the first HSC population in the aorta-gonad-mesonephros region at E11.5 was not significantly aff...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-66381 | biostudies-arrayexpress
TranscriptomicsATF4 governs functional expansion of hematopoietic stem cells partially via Angptl3 in the fetal liver microenvironment (RNA-Seq)
In this study, we demonstrated that deletion of the activating transcription factor 4 (ATF4) resulted in severely impaired HSC expansion in the fetal liver at E12.5 and E15.5. In contrast, generation of the first HSC population in the aorta-gonad-mesonephros region at E11.5 was not significantly aff...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-66380 | biostudies-arrayexpress
TranscriptomicsGene Expression Study in WT and ATF4 KO embryonic neurons
Oxidative stress is pathogenic in neurological diseases including stroke. The identity of oxidative stress-inducible transcription factors and their role(s) in propagating the death cascade are poorly understood. Microarray analysis of neurons undergoing oxidative stress showed significant induction...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-10470 | biostudies-arrayexpress
ProteomicsIntricate coupling between the transactivation and basic-leucine zipper domains governs the CK2-dependent phosphorylation of ATF4
Most transcription factors possess at least one long intrinsically disordered transactivation domain that binds to a variety of co-activators and co-repressors and plays a key role in modulating the transcriptional activity. Despite the crucial importance of these mechanisms, the structural and func...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029704 | Pride
Atf4 Intrinsically disordered domain Phosphorylation Lc-msms 
TranscriptomicsEffect of muscle-specific ATF4 gene knockout (ATF4 mKO) on skeletal muscle mRNA levels in aged mice.
For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Quadriceps femoris muscles were harvested from 22-month-old muscle-specfic ATF4 knockout (ATF4 mKO) mice and littermate controls. mR...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-72658 | biostudies-arrayexpress
TranscriptomicsRNA-Seq experiment to identify genes regulated by ATF4
Activating Transcription Factor 4 (ATF4) is a transcription factor induced by the integrated stress response (ISR). This experiment is a genome-wide profiling of ATF4-dependent RNA expression in human HAP-1 cells. HAP-1 is a near-haploid human cell line that was derived from KBM-7 cells isolated fro...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-69308 | biostudies-arrayexpress
Transcriptomicsp53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization
p53 regulates a distinct subset of skeletal muscle mRNAs during immobilization-induced skeletal muscle atrophy For additional details see Fox et al, p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab. 2014 Aug 1;30...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-62897 | biostudies-arrayexpress
GenomicsGenome-wide analysis of ATF4 binding in histidinol-treated cells
Activating Transcription Factor 4 (ATF4) is a transcription factor induced by the integrated stress response (ISR). This experiment is a genome-wide occupancy profiling of ATF4 in human HAP1 cells. HAP1 is a near-haploid human cell line that was derived from KBM-7 cells isolated from a patient with ...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-69304 | biostudies-arrayexpress
TranscriptomicsEffect of ATF4 overexpression on mRNA levels in differentiated C2C12 myotubes.
ATF4 is a bZIP transcription factor that that promotes skeletal muscle atrophy. The goal of these studies was to determine the effects of ATF4 overexpression on mRNA levels in differentiated C2C12 myotubes. For additional details see Ebert et al, Stress-Induced Skeletal Muscle Gadd45a Expression Rep...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-39194 | biostudies-arrayexpress
TranscriptomicsEffect of ATF4 gene knockout on skeletal muscle mRNA levels in fasted mice.
ATF4 is a fasting-induced trascription factor that promotes skeletal muscle atrophy. The goal of these studies was to determine how of loss of ATF4 affects skeletal muscle mRNA expression. For additional details see Ebert et al, Stress-Induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei ...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-39193 | biostudies-arrayexpress
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