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TranscriptomicsATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
Analysis of the effects of ATM loss on gene expression to identify causes of neurodegeneration. ATM levels were reduced ubiquitously via the temperature-sensitive ATM^8 allele, or via tissue-specific RNAi of ATM (ATMi) using the Gal4/UAS expression system in neurons (Elav-GAL4 and ElavC155-GAL4) or...
ORGANISM(S): Drosophila melanogaster 
2011-12-10 | E-GEOD-34315 | biostudies-arrayexpress
no omics definedTranscription profiling of wild type and Atm-/- mouse lymph nodes treated with ionizing radiation
The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a maste...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2118 | biostudies-arrayexpress
ProteomicsTargeted mass spectrometry enables quantification of novel pharmacodynamic biomarkers of ATM kinase inhibitors
ATM is a serine/threonine protein kinase that is responsible for initiation of DNA repair of double-stranded breaks and is a therapeutic target in cancer. A lack of analytically robust and multiplexed assays has hampered mechanistic studies of action and determination of optimal, robust pharmacodyna...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD026103 | Pride
Human Lymphoblast Atm Phosphorylation 
TranscriptomicsGenomic copy number profiling of different generations of Atm-/-TERT-ER T-cell lymphomas and associated resistant tumors following telomerase inhibition
Genomic copy numbers of various generations of Atm-/-TERT-ER mice treated with 4-OHT or vehicle were profiled. Genomic copy numbers of transplanted G3 Atm-/-TERT-ER T-cell lymphomas with telomerase or ALT T-cell lymphomas were developed in various generations of Atm-/-TERT-ER mice with 4-OHT or veh...
ORGANISM(S): Mus musculus 
2012-01-17 | E-GEOD-35045 | biostudies-arrayexpress
ProteomicsATM Inhibition Exploits Checkpoint Defects and ATM-Dependent Double Strand Break Repair in TP53-Mutant Glioblastoma
Determining the balance between DNA double strand break repair (DSBR) pathways is essential for understanding treatment response in cancer. We report a novel method for simultaneously measuring non-homologous end joining (NHEJ), homologous recombination (HR), and microhomology-mediated end joining (...
ORGANISM(S): Homo sapiens (Human) 
2024-03-08 | PXD047837 | Pride
Dna double strand break repair Tp53-mutant glioblastoma Atm inhibition 
ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
GenomicsInhibition of ATM in Mouse-derived lung fibroblasts
Inhibition of ATM in Mouse-derived lung fibroblasts
PRJNA757628 | ENA
GenomicsEffect of ATM inhibition in primary endothelial cells
Effect of ATM inhibition in primary endothelial cells
PRJNA589641 | ENA
GenomicsInhibition of the ATM kinase rescues planarian regeneration after lethal radiation
Inhibition of the ATM kinase rescues planarian regeneration after lethal radiation
PRJNA787217 | ENA
TranscriptomicsRNA-seq of ATM-knockout human embryonic stem-cells (h-pES10) treated with the LATS1/2 inhibitor Lats-IN-1 (TRULI) for 24 h against untreated cells
LATS1/2 are canonical Hippo signaling pathway components. Our genome-wide screen indicated a synthetic viable effect of Hippo pathway inhibition in ATM-depleted human embryonic and neural progenitor cells. This experiment was designed in order to get mechanistic insights regarding the molecular effe...
ORGANISM(S): Homo sapiens 
2024-01-10 | E-MTAB-12600 | biostudies-arrayexpress
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