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ProteomicsCalreticulin mutated hematopoietic cells are vulnerable to ATR-CHK1 pathway inhibition
Disease frameshift mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF). To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we aimed to search for small molecule drugs th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD026803 | Pride
Mouse Mpn Calreticulin mutant Myeloproliferative neoplasms Atr-chk1 pathway 
ProteomicsThe phosphoproteomics study of Chk1 and ATR inhibitors regulation on cells
Ataxia Telangiectasia and Rad3-related (ATR) and Checkpoint Kinase 1 (Chk1) are crucial kinases in the DNA Damage Response (DDR) pathway. While the roles of ATR and Chk1 within the DDR are well-established, their roles in mitosis are not fully understood. Here, we describe that the ATR-Chk1 pathway ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD058541 | Pride
Phosphoproteomics Cdk1 Inhibitor Chk1 
UnknownThe mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation.
Not available
S-EPMC12451630 | biostudies-literature
UnknownMultiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates.
Not available
S-EPMC3146532 | biostudies-literature
TranscriptomicsRocaglamide selectively inhibits the G1-S-phase transition in cancer cells by activation of the ATM/ATR-mediated Chk1/2 cell cycle checkpoints
The cell division cycle is tightly controlled in normal cells. Cancer cells are characterized by deregulation in cell division cycle, which is associated with increased DNA replication and elevated cellular proliferation. Recently, genetic studies indicate that cyclin dependent kinases CDK2, CDK4 an...
ORGANISM(S): Homo sapiens 
2013-10-12 | E-GEOD-41072 | biostudies-arrayexpress
UnknownNatural products targeting the ATR-CHK1 signaling pathway in cancer therapy.
Not available
S-EPMC9590097 | biostudies-literature
UnknownDUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.
Not available
S-EPMC7474466 | biostudies-literature
UnknownREV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts.
Not available
S-EPMC4426025 | biostudies-literature
UnknownCancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.
Not available
S-EPMC4713868 | biostudies-literature
UnknownExploring the ATR-CHK1 pathway in the response of doxorubicin-induced DNA damages in acute lymphoblastic leukemia cells.
Not available
S-EPMC10406704 | biostudies-literature
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