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ProteomicsLC/MS/MS identification of phosphor-sites of Human ATR-domain (330-616 aa) expressed and purified from E. coli after in vitro phosphorylation.
Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase), and PP2A regulate ATRS428P429 isomerization, they act oppositely depending on the phosphorylation status of ATR(S428). In addition, whether the isomerization at the ATR-S428P429 motif along with the BH3 domain accessibility is exclusively respons...
ORGANISM(S): Escherichia coli 
2026-09-08 | PXD054542 | Pride
Biotin modification Atr-domain Cis/trans prolyl isomerization Mass protein footprinting Bh3-like domain 
UnknownNUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR.
Not available
S-EPMC7174393 | biostudies-literature
UnknownThe ATM- and ATR-related SCD domain is over-represented in proteins involved in nervous system development.
Not available
S-EPMC4705472 | biostudies-literature
UnknownThe ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase.
Not available
S-EPMC6121618 | biostudies-literature
ProteomicsHuman serine/threonine protein kinase ATR LC-MS/MS
ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engage in antiapoptotic role at mitochondria following DNA damage. The different functions of ATR in the nucleus and cytoplasm are ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031385 | Pride
Biotin modification Cis/trans prolyl isomerization Mass protein footprinting Bh3-like domain Atr 
UnknownThe Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.
Not available
S-EPMC3386226 | biostudies-literature
TranscriptomicsTranscription profiling of atm mutant, adm mutant and wild type whole plants and roots of Arabdiposis after gamma ray irradiation in a time series
Whole seedlings of wild type (4d) and atm mutants (4d) have been analyzed after a gamma ray irradiation of 0.75h, 1.5h, 3h & 5h (time course). Roots of wt (4d), atm (3d) and atr (4d) mutants have been analyzed after a 1h irradiation.

Ataxia Telangiectasia Mutated (ATM), encodes a large prote...
ORGANISM(S): Arabidopsis thaliana 
2006-10-30 | E-MEXP-780 | biostudies-arrayexpress
ProteomicsActivation of the ATR kinase by the RPA-binding protein ETAA1
The ATR kinase is a master regulator of cellular responses to DNA damage and replication stress that is activated by a complex mechanism involving its binding partner ATRIP, RPA-coated ssDNA, the 9-1-1 complex and TopBP1. Here, we discovered a new ATR activation mechanism in human cells, mediated by...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2016-09-30 | PXD003529 | Pride
Dsb repair Chromass Dna damage response 
ProteomicsROCK1 restrains STING pathway activation through promoting ATR-mediated DNA damage repair in prostate cancer
The stimulator of interferon genes (STING) pathway is a central regulator of antitumor immunity, yet its activation in prostate cancer remains limited. Here, through kinome-focused CRISPR screening and p-STING-based flow sorting, we identify ROCK1 as a repressor of STING signaling in prostate cancer...
ORGANISM(S): Homo Sapiens 
2026-08-18 | PXD082898 |
UnknownProlyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions.
Not available
S-EPMC9204103 | biostudies-literature
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